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Mouse Anti-LIME1 Recombinant Antibody (CBYCL-333) (CBMAB-L0234-YC)

Provided herein is a Mouse monoclonal antibody against Human LIME1. The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all LIME1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-333
Antibody Isotype
IgG2a
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide from human LIME1 / LIME
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, with 15 mM sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lck interacting transmembrane adaptor 1
Introduction
LIME1 is a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively.
Entrez Gene ID
54923
UniProt ID
Q9H400
Alternative Names
LIME; dJ583P15.4; LP8067
Function
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
B cell receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of MAP kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Regulation of release of sequestered calcium ion into cytosolManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
T cell receptor signaling pathwayIEA:InterPro
Cellular Location
Cell membrane
Present in lipid rafts. Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell.
Topology
Extracellular: 1-6
Helical: 7-27
Cytoplasmic: 28-295
PTM
Palmitoylation of Cys-28 and Cys-31 is required for raft targeting.
Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation; which leads to the recruitment of SH2-containing proteins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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