Mouse Anti-LIN28A Recombinant Antibody (A909) (CBMAB-AP11494LY)

Name: Mouse Anti-LIN28A Recombinant Antibody (A909)
SKU: CBMAB-AP11494LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A909

Application

Immunogen

Recombinant full length Human LIN28A

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LIN28A

Entrez Gene ID

Human	79727
Mouse	83557

UniProt ID

Human	Q9H9Z2
Mouse	Q8K3Y3

Alternative Names

Protein lin-28 homolog A, Lin-28A, Zinc finger CCHC domain-containing protein 1, LIN28A, CSDD1, LIN28, ZCCHC1

Function

MB0149

Biological Process

Cellular response to glucose stimulusISS:BHF-UCL
Germ cell developmentIEA:Ensembl
miRNA catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of glial cell differentiationIEA:Ensembl
Negative regulation of translationISS:UniProtKB
Positive regulation of cell proliferation involved in kidney developmentIEA:Ensembl
Positive regulation of cytoplasmic translationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron differentiationIEA:Ensembl
Positive regulation of production of miRNAs involved in gene silencing by miRNAISS:BHF-UCL
Positive regulation of protein kinase B signalingISS:BHF-UCL
Positive regulation of TOR signalingISS:BHF-UCL
Pre-miRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
RNA 3' uridylationIEA:Ensembl
RNA 3'-end processingManual Assertion Based On ExperimentIMP:UniProtKB
Stem cell differentiationIEA:Ensembl
Stem cell population maintenanceManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Rough endoplasmic reticulum
Cytoplasm, P-body
Cytoplasm, Stress granule
Nucleus, nucleolus
Predominantly cytoplasmic (PubMed:22118463).
In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity).
Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744).
Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity).

Wu, K., Ahmad, T., & Eri, R. (2022). LIN28A: A multifunctional versatile molecule with future therapeutic potential. World journal of biological chemistry, 13(2), 35.

Jouan, Y., Bouchemla, Z., Bardèche-Trystram, B., Sana, J., Andrique, C., Ea, H. K., ... & Hay, E. (2022). Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice. Science Advances, 8(34), eabn3106.

Nathan, F. M., Ohtake, Y., Wang, S., Jiang, X., Sami, A., Guo, H., ... & Li, S. (2020). Upregulating Lin28a promotes axon regeneration in adult mice with optic nerve and spinal cord injury. Molecular Therapy, 28(8), 1902-1917.

Jung, G. S., Hwang, Y. J., Choi, J. H., & Lee, K. M. (2020). Lin28a attenuates TGF-β-induced renal fibrosis. BMB reports, 53(11), 594.

Lu, J., Liu, X., Zheng, J., Song, J., Liu, Y., Ruan, X., ... & Xue, Y. (2020). Lin28A promotes IRF6-regulated aerobic glycolysis in glioma cells by stabilizing SNHG14. Cell death & disease, 11(6), 447.

Zhang, J., Xu, A., Miao, C., Yang, J., Gu, M., & Song, N. (2019). Prognostic value of Lin28A and Lin28B in various human malignancies: a systematic review and meta-analysis. Cancer cell international, 19(1), 1-8.

Haq, S., Das, S., Kim, D. H., Chandrasekaran, A. P., Hong, S. H., Kim, K. S., & Ramakrishna, S. (2019). The stability and oncogenic function of LIN28A are regulated by USP28. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1865(3), 599-610.

Sang, H., Wang, D., Zhao, S., Zhang, J., Zhang, Y., Xu, J., ... & Liu, N. (2019). Dppa3 is critical for Lin28a-regulated ES cells naïve–primed state conversion. Journal of Molecular Cell Biology, 11(6), 474-488.

Ma, H., Yu, S., Liu, X., Zhang, Y., Fakadej, T., Liu, Z., ... & Liu, J. (2019). Lin28a regulates pathological cardiac hypertrophic growth through Pck2-mediated enhancement of anabolic synthesis. Circulation, 139(14), 1725-1740.

Xia, X., Teotia, P., & Ahmad, I. (2018). Lin28a regulates neurogliogenesis in mammalian retina through the Igf signaling. Developmental biology, 440(2), 113-128.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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