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Mouse Anti-LMNB1 Recombinant Antibody (119D5-F1) (CBMAB-L1812-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lamin B1 (LMNB1). The antibody can be used for immunoassay techniques, such as WB, Dot, ELISA, FC, ICC, IF, IHC.
See all LMNB1 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Sheep, Rabbit, Cattle, Dog
Clone
119D5-F1
Antibody Isotype
IgG1, κ
Application
WB, Dot, ELISA, FC, ICC, IF, IHC

Basic Information

Immunogen
Purified rat liver lamins.
Specificity
Human, Mouse, Rat, Sheep, Rabbit, Cattle, Dog
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lamin B1
Introduction
LMNB1 is one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is related to autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human4001
Mouse16906
Rat116685
Cattle540643
Dog474663
Sheep100037680
Rabbit100346094
UniProt ID
HumanP20700
MouseP14733
RatP70615
CattleA7YY47
DogJ9P3G1
SheepW5Q9T3
RabbitG1ST69
Alternative Names
LMN; ADLD; LMN2; LMNB
Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Biological Process
Nuclear envelope organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus lamina
Involvement in disease
Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD):
A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
Microcephaly 26, primary, autosomal dominant (MCPH26):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH26 is an autosomal dominant, progressive form apparent at birth or in early infancy. It is associated with relative short stature, variable severity of intellectual disability, and neurological features as the core symptoms. Brain imaging shows a simplified gyral pattern of the cortex and abnormal corpus callosum in some patients.
PTM
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Huang, Y., Zhang, L., Liu, T., & Liang, E. (2023). LMNB1 targets FOXD1 to promote progression of prostate cancer. Experimental and Therapeutic Medicine, 26(5), 1-9.

Hong, J. H., Liang, S. T., Wang, A. S. S., Yeh, C. M., Huang, H. P., Sun, C. D., ... & Pu, Y. S. (2022). LMNB1, a potential marker for early prostate cancer progression. American Journal of Cancer Research, 12(7), 3390.

Li, J., Sun, Z., Cui, Y., Qin, L., Wu, F., Li, Y., ... & Li, X. (2022). Knockdown of LMNB1 inhibits the proliferation of lung adenocarcinoma cells by inducing DNA damage and cell senescence. Frontiers in oncology, 12, 913740.

Tang, D., Luo, H., Xie, A., He, Z., Zou, B., Xu, F., ... & Xu, X. (2021). Silencing LMNB1 contributes to the suppression of lung adenocarcinoma development. Cancer Management and Research, 2633-2642.

Zhou, D., Wang, M., Zhang, Y., Wang, K., Zhao, M., Wang, Y., ... & Zhou, X. (2021). Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas. Bioscience reports, 41(5), BSR20210231.

Ding, B., Tang, Y., Ma, S., Akter, M., Liu, M. L., Zang, T., & Zhang, C. L. (2021). Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia. Journal of Neuroscience, 41(9), 2024-2038.

Cristofoli, F., Moss, T., Moore, H. W., Devriendt, K., Flanagan-Steet, H., May, M., ... & Van Esch, H. (2020). De novo variants in LMNB1 cause pronounced syndromic microcephaly and disruption of nuclear envelope integrity. The American Journal of Human Genetics, 107(4), 753-762.

Yang, Z., Sun, Q., Guo, J., Wang, S., Song, G., Liu, W., ... & Tang, H. (2019). GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells. Autophagy, 15(4), 668-685.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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