Rabbit Anti-LMNB1 Recombinant Antibody (D4Q4Z) (CBMAB-CP1339-LY)

Name: Rabbit Anti-LMNB1 Recombinant Antibody (D4Q4Z)
SKU: CBMAB-CP1339-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D4Q4Z

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu118 of human lamin B1 protein.

Specificity

Human, Mouse, Rat, Monkey, Pig

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lamin B1

Entrez Gene ID

Human	4001
Mouse	16906
Rat	116685
Monkey	703575
Pig	100513342

UniProt ID

Human	P20700
Mouse	P14733
Rat	P70615
Monkey	A0A2K5VC86
Pig	F1RKM0

Function

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Biological Process

Nuclear envelope organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus lamina

Involvement in disease

Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD):
A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
Microcephaly 26, primary, autosomal dominant (MCPH26):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH26 is an autosomal dominant, progressive form apparent at birth or in early infancy. It is associated with relative short stature, variable severity of intellectual disability, and neurological features as the core symptoms. Brain imaging shows a simplified gyral pattern of the cortex and abnormal corpus callosum in some patients.

PTM

B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Huang, Y., Zhang, L., Liu, T., & Liang, E. (2023). LMNB1 targets FOXD1 to promote progression of prostate cancer. Experimental and Therapeutic Medicine, 26(5), 1-9.

Hong, J. H., Liang, S. T., Wang, A. S. S., Yeh, C. M., Huang, H. P., Sun, C. D., ... & Pu, Y. S. (2022). LMNB1, a potential marker for early prostate cancer progression. American Journal of Cancer Research, 12(7), 3390.

Li, J., Sun, Z., Cui, Y., Qin, L., Wu, F., Li, Y., ... & Li, X. (2022). Knockdown of LMNB1 inhibits the proliferation of lung adenocarcinoma cells by inducing DNA damage and cell senescence. Frontiers in oncology, 12, 913740.

Tang, D., Luo, H., Xie, A., He, Z., Zou, B., Xu, F., ... & Xu, X. (2021). Silencing LMNB1 contributes to the suppression of lung adenocarcinoma development. Cancer Management and Research, 2633-2642.

Zhou, D., Wang, M., Zhang, Y., Wang, K., Zhao, M., Wang, Y., ... & Zhou, X. (2021). Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas. Bioscience reports, 41(5), BSR20210231.

Ding, B., Tang, Y., Ma, S., Akter, M., Liu, M. L., Zang, T., & Zhang, C. L. (2021). Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia. Journal of Neuroscience, 41(9), 2024-2038.

Cristofoli, F., Moss, T., Moore, H. W., Devriendt, K., Flanagan-Steet, H., May, M., ... & Van Esch, H. (2020). De novo variants in LMNB1 cause pronounced syndromic microcephaly and disruption of nuclear envelope integrity. The American Journal of Human Genetics, 107(4), 753-762.

Yang, Z., Sun, Q., Guo, J., Wang, S., Song, G., Liu, W., ... & Tang, H. (2019). GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells. Autophagy, 15(4), 668-685.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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