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Mouse Anti-LMNB1 Recombinant Antibody (4B10) (CBMAB-A5012-LY)

The product is antibody recognizes LMNB1. The antibody 4B10 immunoassay techniques such as: WB, ELISA.
See all LMNB1 antibodies
Published Data
Fig.1 Western Blot analysis in TF-1 cells.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4B10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
LMNB1 (NP_005564.1, 107 a.a. ~ 186 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lamin B1
Introduction
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. [provided by RefSeq]
Entrez Gene ID
Human4001
Mouse16906
UniProt ID
HumanP20700
MouseP14733
Alternative Names
ADLD; LMN; LMN2; LMNB; MGC111419
Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Biological Process
Nuclear envelope organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus lamina
Involvement in disease
Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD):
A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
Microcephaly 26, primary, autosomal dominant (MCPH26):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH26 is an autosomal dominant, progressive form apparent at birth or in early infancy. It is associated with relative short stature, variable severity of intellectual disability, and neurological features as the core symptoms. Brain imaging shows a simplified gyral pattern of the cortex and abnormal corpus callosum in some patients.
PTM
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Huang, Y., Zhang, L., Liu, T., & Liang, E. (2023). LMNB1 targets FOXD1 to promote progression of prostate cancer. Experimental and Therapeutic Medicine, 26(5), 1-9.

Hong, J. H., Liang, S. T., Wang, A. S. S., Yeh, C. M., Huang, H. P., Sun, C. D., ... & Pu, Y. S. (2022). LMNB1, a potential marker for early prostate cancer progression. American Journal of Cancer Research, 12(7), 3390.

Li, J., Sun, Z., Cui, Y., Qin, L., Wu, F., Li, Y., ... & Li, X. (2022). Knockdown of LMNB1 inhibits the proliferation of lung adenocarcinoma cells by inducing DNA damage and cell senescence. Frontiers in oncology, 12, 913740.

Tang, D., Luo, H., Xie, A., He, Z., Zou, B., Xu, F., ... & Xu, X. (2021). Silencing LMNB1 contributes to the suppression of lung adenocarcinoma development. Cancer Management and Research, 2633-2642.

Zhou, D., Wang, M., Zhang, Y., Wang, K., Zhao, M., Wang, Y., ... & Zhou, X. (2021). Screening and identification of LMNB1 and DLGAP5, two key biomarkers in gliomas. Bioscience reports, 41(5), BSR20210231.

Ding, B., Tang, Y., Ma, S., Akter, M., Liu, M. L., Zang, T., & Zhang, C. L. (2021). Disease modeling with human neurons reveals LMNB1 dysregulation underlying DYT1 dystonia. Journal of Neuroscience, 41(9), 2024-2038.

Cristofoli, F., Moss, T., Moore, H. W., Devriendt, K., Flanagan-Steet, H., May, M., ... & Van Esch, H. (2020). De novo variants in LMNB1 cause pronounced syndromic microcephaly and disruption of nuclear envelope integrity. The American Journal of Human Genetics, 107(4), 753-762.

Yang, Z., Sun, Q., Guo, J., Wang, S., Song, G., Liu, W., ... & Tang, H. (2019). GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells. Autophagy, 15(4), 668-685.

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For research use only. Not intended for any clinical use.

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