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Rabbit Anti-LMNB2 Recombinant Antibody (D8P3U) (CBMAB-CP1340-LY)

The product is antibody recognizes LMNB2. The antibody D8P3U immunoassay techniques such as: WB,IP,IF (ICC).
See all LMNB2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D8P3U
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys435 of human lamin B2 protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LMNB2
Entrez Gene ID
Human84823
Monkey100426602
UniProt ID
HumanQ03252
MonkeyA0A2K5VL33
Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Cellular Location
Nucleus lamina
Involvement in disease
Partial acquired lipodystrophy (APLD):
A rare childhood disease characterized by loss of subcutaneous fat from the face and trunk. Fat deposition on the pelvic girdle and lower limbs is normal or excessive. Most frequently, onset between 5 and 15 years of age. Most affected subjects are females and some show no other abnormality, but many develop glomerulonephritis, diabetes mellitus, hyperlipidemia, and complement deficiency. Mental retardation in some cases. APLD is a sporadic disorder of unknown etiology.
Epilepsy, progressive myoclonic 9 (EPM9):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM9 is an autosomal recessive form characterized by myoclonus, tonic-clonic seizures, ataxia, and delayed psychomotor development.
Microcephaly 27, primary, autosomal dominant (MCPH27):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH27 is an autosomal dominant form apparent in early childhood and associated with global developmental delay, delayed walking, inability to walk, impaired intellectual development, and poor or absent speech. Brain imaging may show enlarged ventricles or gyral abnormalities in some patients.
PTM
B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.

Wang, J., Morgan, W., Saini, A., Liu, T., Lough, J., & Han, L. (2022). Single-cell transcriptomic profiling reveals specific maturation signatures in human cardiomyocytes derived from LMNB2-inactivated induced pluripotent stem cells. Frontiers in Cell and Developmental Biology, 10, 895162.

Qiu, M., Chen, M., Lan, Z., Liu, B., Xie, J., & Li, X. (2022). Plasmacytoma variant translocation 1 stabilized by EIF4A3 promoted malignant biological behaviors of lung adenocarcinoma by generating circular RNA LMNB2. Bioengineered, 13(4), 10123-10140.

Varlet, A. A., Desgrouas, C., Jebane, C., Bonello-Palot, N., Bourgeois, P., Levy, N., ... & Beliard, S. (2021). A rare mutation in LMNB2 associated with lipodystrophy drives premature cell senescence. Cells, 11(1), 50.

Dong, C. H., Jiang, T., Yin, H., Song, H., Zhang, Y., Geng, H., ... & Song, J. (2021). LMNB2 promotes the progression of colorectal cancer by silencing p21 expression. Cell Death & Disease, 12(4), 331.

Mu, W., Guo, L., Liu, Y., Yang, H., Ning, S., & Lv, G. (2021). Long noncoding RNA SNHG1 regulates LMNB2 expression by sponging miR-326 and promotes cancer growth in hepatocellular carcinoma. Frontiers in Oncology, 11, 784067.

Kong, W., Wu, Z., Yang, M., Zuo, X., Yin, G., & Chen, W. (2020). LMNB2 is a prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma. IUBMB life, 72(12), 2672-2685.

Su, X., Feng, X., Gao, C., Wang, G., & Liu, L. (2020). ROR promotes the proliferation and migration of esophageal cancer through regulating miR-145/LMNB2 signal axis. American Journal of Translational Research, 12(11), 7223.

Li, X. N., Yang, H., & Yang, T. (2020). miR-122 inhibits hepatocarcinoma cell progression by targeting LMNB2. Oncology Research, 28(1), 41.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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