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Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807)


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Tested Data
Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807) in WB
Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807) in WB
Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807) in WB
Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807) in WB
Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807) in ELISA
Mouse Anti-LMO2 Recombinant Antibody (CBT4093) (V2LY-0625-LY2807) in ELISA

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4093
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human LMO2 (AA: 1-158) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LIM domain only 2
Entrez Gene ID
4005
UniProt ID
P25791
Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Biological Process
Cellular response to thyroid hormone stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
More Infomation

Park, C. G., Choi, S. H., Lee, S. Y., Eun, K., Park, M. G., Jang, J., ... & Kim, H. (2022). Cytoplasmic LMO2-LDB1 complex activates STAT3 signaling through interaction with gp130-JAK in glioma stem cells. Cells, 11(13), 2031.

Chapman, J., Verdun, R. E., & Lossos, I. S. (2021). Low LIM-domain only 2 (LMO2) expression in aggressive B cell lymphoma correlates with MYC and MYC/BCL2 rearrangements, especially in germinal center cell-type tumors. Leukemia & lymphoma, 62(10), 2547-2550.

Brar, N., Butzmann, A., Kumar, J., Peerani, R., Morgan, E. A., Grigoriadis, G., ... & Ohgami, R. S. (2020). LIM domain only 2 (LMO2) expression distinguishes T‐lymphoblastic leukemia/lymphoma from indolent T‐lymphoblastic proliferations. Histopathology, 77(6), 984-988.

Wang, W., Chen, Y., Chang, Y., & Sun, W. (2020). Biochemical feature of LMO2 interactome and LMO2 function prospect. Medical science monitor basic research, 26, e924421-1.

Li, L., Mitra, A., Zhao, B., Choi, S., Lee, J., Stamos, D., ... & Dave, U. (2019). LIM Domain Protein 1 (Ldb1) Is Required for Lmo2 Oncogene-Induced Thymocyte Self-Renewal and T-Cell Leukemia in a Mouse Model of Human T-ALL.

Morishima, T., Krahl, A. C., Nasri, M., Xu, Y., Aghaallaei, N., Findik, B., ... & Skokowa, J. (2019). LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. Blood, The Journal of the American Society of Hematology, 134(14), 1159-1175.

Miyashita, K., Kitajima, K., Goyama, S., Kitamura, T., & Hara, T. (2018). Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochemical and biophysical research communications, 495(3), 2310-2316.

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For research use only. Not intended for any clinical use.

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