LMO2
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.
Full Name
LIM domain only 2
Function
Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
Biological Process
Cellular response to thyroid hormone stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Nucleus
Involvement in disease
A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
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Anti-LMO2 antibodies
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CompareTarget: LMO2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1875
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9-1
Application*: WB, P, IC, IF
Target: LMO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 9H9
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4093
Application*: F
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: IHC615
Application*: P, E, IH
Target: LMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYCL-397
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-396
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-395
Application*: E, WB, F
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-394
Application*: IH, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-393
Application*: IF, P, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYCL-392
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9-3D11
Application*: P
Target: LMO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP51
Application*: P, WB, F
Target: LMO2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1877
Application*: WB, IP, IF, E
Target: LMO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP3257
Application*: F, IP, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6B8
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJL-1876
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D8
Application*: WB, F
Target: LMO2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4D3
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-1873
Application*: WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D7
Application*: WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B3
Application*: E, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1872
Application*: WB, IH
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1870
Application*: P, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1869
Application*: P
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A9-3B11
Application*: WB, IH, IC, IF, P
Target: LMO2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1868
Application*: F, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B477
Application*: E, F, WB
Target: LMO2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10D368
Application*: IF, IH, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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