Rabbit Anti-LMO2 Recombinant Antibody (
9H9) (V2LY-0725-LY1393)

Name: Rabbit Anti-LMO2 Recombinant Antibody (9H9)
SKU: V2LY-0725-LY1393
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-LMO2 Recombinant Antibody (9H9) (V2LY-0725-LY1393) in WB

Western Blot
Positive WB detected in: U937 whole cell lysate, U87 whole cell lysate, PC3 whole cell lysate, MCF-7 whole cell lysate
All lanes: LMO2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 19, 26, 6 kDa
Observed band size: 20-25, 90-100 kDa

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

9H9

Application

ELISA, WB

Immunogen

A synthesized peptide derived from human LMO2.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LIM domain only 2

Entrez Gene ID

4005

UniProt ID

P25791

Function

Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.

Biological Process

Cellular response to thyroid hormone stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.

Park, C. G., Choi, S. H., Lee, S. Y., Eun, K., Park, M. G., Jang, J., ... & Kim, H. (2022). Cytoplasmic LMO2-LDB1 complex activates STAT3 signaling through interaction with gp130-JAK in glioma stem cells. Cells, 11(13), 2031.

Chapman, J., Verdun, R. E., & Lossos, I. S. (2021). Low LIM-domain only 2 (LMO2) expression in aggressive B cell lymphoma correlates with MYC and MYC/BCL2 rearrangements, especially in germinal center cell-type tumors. Leukemia & lymphoma, 62(10), 2547-2550.

Brar, N., Butzmann, A., Kumar, J., Peerani, R., Morgan, E. A., Grigoriadis, G., ... & Ohgami, R. S. (2020). LIM domain only 2 (LMO2) expression distinguishes T‐lymphoblastic leukemia/lymphoma from indolent T‐lymphoblastic proliferations. Histopathology, 77(6), 984-988.

Wang, W., Chen, Y., Chang, Y., & Sun, W. (2020). Biochemical feature of LMO2 interactome and LMO2 function prospect. Medical science monitor basic research, 26, e924421-1.

Li, L., Mitra, A., Zhao, B., Choi, S., Lee, J., Stamos, D., ... & Dave, U. (2019). LIM Domain Protein 1 (Ldb1) Is Required for Lmo2 Oncogene-Induced Thymocyte Self-Renewal and T-Cell Leukemia in a Mouse Model of Human T-ALL.

Morishima, T., Krahl, A. C., Nasri, M., Xu, Y., Aghaallaei, N., Findik, B., ... & Skokowa, J. (2019). LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. Blood, The Journal of the American Society of Hematology, 134(14), 1159-1175.

Miyashita, K., Kitajima, K., Goyama, S., Kitamura, T., & Hara, T. (2018). Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels. Biochemical and biophysical research communications, 495(3), 2310-2316.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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