Mouse Anti-LMOD1 Recombinant Antibody (CBYCL-405) (CBMAB-L0306-YC)

Name: Mouse Anti-LMOD1 Recombinant Antibody (CBYCL-405)
SKU: CBMAB-L0306-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-405

Application

ELISA, WB

Immunogen

Recombiant full length LMOD1 protein

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-270

More Infomation

Target

Full Name

leiomodin 1 (smooth muscle)

Introduction

The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy.

Entrez Gene ID

25802

UniProt ID

P29536

Alternative Names

SMLMOD; 64kD; 1D; SM-LMOD; D1

Function

Required for proper contractility of visceral smooth muscle cells (PubMed:28292896).
Mediates nucleation of actin filaments.

Biological Process

Actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Actin nucleationManual Assertion Based On ExperimentIDA:UniProtKB
Muscle contractionManual Assertion Based On ExperimentIBA:GO_Central
Myofibril assemblyManual Assertion Based On ExperimentIBA:GO_Central
Pointed-end actin filament cappingIEA:InterPro
Positive regulation of actin filament polymerizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, myofibril, sarcomere
Cytoplasm, cytoskeleton
Colocalizes with actin filaments in sarcomeres.

Involvement in disease

Megacystis-microcolon-intestinal hypoperistalsis syndrome 3 (MMIHS3):
A form of megacystis-microcolon-intestinal hypoperistalsis syndrome, a congenital visceral myopathy primarily affecting females, and characterized by loss of smooth muscle contraction in the bladder and intestine. Affected individuals present at birth with functional obstruction of intestine, microcolon, dilation of bladder, and secondary hydronephrosis. The majority of cases have a fatal outcome due to malnutrition and sepsis, followed by multiorgan failure. MMIHS3 inheritance is autosomal recessive.

Fournier, N., & Fabre, A. (2022). Smooth muscle motility disorder phenotypes: A systematic review of cases associated with seven pathogenic genes (ACTG2, MYH11, FLNA, MYLK, RAD21, MYL9 and LMOD1). Intractable & Rare Diseases Research, 11(3), 113-119.

Tan, Y., Chen, Q., Pan, S., An, W., Xu, H., Xing, Y., & Zhang, J. (2022). LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway. BMC cancer, 22(1), 474.

Kosiński, K., Malinowski, D., Safranow, K., Dziedziejko, V., & Pawlik, A. (2022). PECAM1, COL4A2, PHACTR1, and LMOD1 Gene Polymorphisms in Patients with Unstable Angina. Journal of Clinical Medicine, 11(2), 373.

Liu, K., Lu, L., Chen, S., Gu, B., Cai, H., Wang, Y., & Cai, W. (2022). Loss‐of‐function variants within LMOD1 actin‐binding site 2 cause pediatric intestinal pseudo‐obstruction by impairing protein stability and actin nucleation. The FASEB Journal, 36(3), e22194.

Qiao, X., Fu, S., Duan, X., Zuo, Y., Zhu, X., Wang, H., & Wang, J. (2021). MYLK, CNN1, TAGLN and LMOD1 identified as potential prognostic biomarkers for bladder cancer using bioinformatics analysis.

Nanda, V., Wang, T., Pjanic, M., Liu, B., Quertermous, T., Miano, J., ... & Miller, C. L. (2018). Regulatory Mechanism of Lmod1 Mediated Predisposition to Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(Suppl_1), A619-A619.

Nanda, V., Wang, T., Pjanic, M., Liu, B., Nguyen, T., Matic, L. P., ... & Miller, C. L. (2018). Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLoS genetics, 14(11), e1007755.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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