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Mouse Anti-LOXL4 Recombinant Antibody (CBYJL-1913) (CBMAB-L1943-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lysyl Oxidase Like 4 (LOXL4). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LOXL4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1913
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 657-756 from human LOXL4 (NP_115587) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 657-756

Target

Full Name
lysyl oxidase-like 4
Introduction
LOXL4 is a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Entrez Gene ID
84171
UniProt ID
Q96JB6
Alternative Names
LOXC; lysyl oxidase homolog 4; lysyl oxidase related C; lysyl oxidase-like 4 pseudogene; lysyl oxidase-like protein 4; lysyl oxidase-related protein C
Function
May modulate the formation of a collagenous extracellular matrix.
Biological Process
Collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-lysine oxidationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
PTM
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Ma, H. Y., Li, Q., Wong, W. R., N’Diaye, E. N., Caplazi, P., Bender, H., ... & Ding, N. (2023). LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung. Science Advances, 9(21), eadf0133.

Wang, J., Chen, C., Huang, J., Xie, Z., Chen, X., Zheng, Z., ... & Zou, H. (2023). The possibilities of LOXL4 as a prognostic marker for carcinomas. Amino Acids, 1-11.

Altuntaş, O. M., Süslü, N., Tezel, Y. G. G., Dogan, H. T., & Yılmaz, T. (2022). Lysyl Oxidase Like-4 (LOXL4) as a tumor marker and prognosticator in advanced stage laryngeal cancer. Brazilian Journal of Otorhinolaryngology, 88, 968-974.

Ji, Y., You, Y., Wu, Y., Wang, M., He, Q., Zhou, X., ... & Zhao, X. (2022). Overexpression of miR-328-5p influences cell growth and migration to promote NSCLC progression by targeting LOXL4. Annals of Translational Medicine, 10(6).

Yin, H., Wang, Y., Wu, Y., Zhang, X., Zhang, X., Liu, J., ... & Zhang, R. (2020). EZH2-mediated epigenetic silencing of miR-29/miR-30 targets LOXL4 and contributes to tumorigenesis, metastasis, and immune microenvironment remodeling in breast cancer. Theranostics, 10(19), 8494.

Li, R., Wang, Y., Zhang, X., Feng, M., Ma, J., Li, J., ... & Jiang, S. (2019). Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis. Molecular cancer, 18(1), 1-19.

Shao, J., Lu, J., Zhu, W., Yu, H., Jing, X., Wang, Y. L., ... & Wang, X. J. (2019). Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53. Cell Death & Differentiation, 26(11), 2237-2252.

Xie, W., Huang, P., Wu, B., Chen, S., Huang, Z., Wang, J., ... & Zou, H. (2019). Clinical significance of LOXL4 expression and features of LOXL4-associated protein–protein interaction network in esophageal squamous cell carcinoma. Amino Acids, 51, 813-828.

Zhang, Y., Jiang, W. L., Yang, J. Y., Huang, J., Kang, G., Hu, H. B., & Xie, S. (2019). Downregulation of lysyl oxidase‐like 4 LOXL4 by miR‐135a‐5p promotes lung cancer progression in vitro and in vivo. Journal of Cellular Physiology, 234(10), 18679-18687.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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