LOXL4

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq]

Full Name

lysyl oxidase-like 4

Function

May modulate the formation of a collagenous extracellular matrix.

Biological Process

Collagen fibril organizationManual Assertion Based On ExperimentIBA:GO_Central
Peptidyl-lysine oxidationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted, extracellular space

PTM

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.