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Mouse Anti-LRIG3 Recombinant Antibody (CBYCL-456) (CBMAB-L0357-YC)

Provided herein is a Mouse monoclonal antibody against Human LRIG3. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LRIG3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-456
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine-rich repeats and immunoglobulin-like domains 3
Introduction
LRIG3 may play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1.
Entrez Gene ID
UniProt ID
Alternative Names
LIG3
Function
May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity).
Biological Process
Otolith morphogenesisIEA:Ensembl
Cellular Location
Cell membrane
Cytoplasmic vesicle membrane
Detected in cytoplasmic vesicles when coexpressed with ERBB4.
Topology
Helical: 810-830

Li, Y., Wang, W., Hou, X., Huang, W., Zhang, P., He, Y., ... & Guo, D. (2023). Glioma-derived LRIG3 interacts with NETO2 in tumor-associated macrophages to modulate microenvironment and suppress tumor growth. Cell Death & Disease, 14(1), 28.

Zhou, H., Cao, J., Yang, F., Fan, D., Li, H., Fan, T., & Sun, P. (2021). Member Domain 3 (LRIG3) Activates Hypoxia-Inducible Factor-1 α/Vascular Endothelial Growth Factor (HIF-1α/VEGF) Pathway to Inhibit the Growth of Bone Marrow Mesenchymal Stem Cells in Glioma. Journal of Biomaterials and Tissue Engineering, 11(5), 1022-1027.

De Vincenti, A. P., Alsina, F. C., Ferrero Restelli, F., Hedman, H., Ledda, F., & Paratcha, G. (2021). Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. Development, 148(16), dev197020.

Peng, C., Chen, H., Li, Y., Yang, H., Qin, P., Ma, B., ... & Guo, D. (2021). LRIG3 suppresses angiogenesis by regulating the PI3K/AKT/VEGFA signaling pathway in glioma. Frontiers in Oncology, 11, 621154.

Qiu, Y., Han, Q., Lu, H., & Shi, C. (2020). miR-196a targeting LRIG3 promotes the proliferation and migration of cervical cancer cells. Cellular and Molecular Biology, 66(7), 180-185.

Sun, S., Gao, J., Zhou, S., Li, Y., Wang, Y., Jin, L., ... & Li, X. (2020). A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling. Journal of Experimental & Clinical Cancer Research, 39(1), 1-13.

Zeng, K., Chen, X., Xu, M., Liu, X., Li, C., Xu, X., ... & Wang, S. (2020). LRIG3 represses cell motility by inhibiting slug via inactivating ERK signaling in human colorectal cancer. IUBMB life, 72(7), 1393-1403.

Chen, Y., Wang, Q., Wang, M., & Li, M. (2019). Overexpressed LRIG3 gene ameliorates prostate cancer through suppression of cell invasion and migration. International journal of biological macromolecules, 124, 1-9.

Cheng, F., Zhang, P., Xiao, Q., Li, Y., Dong, M., Wang, H., ... & Guo, D. (2019). The prognostic and therapeutic potential of LRIG3 and soluble LRIG3 in glioblastoma. Frontiers in Oncology, 9, 447.

Yang, K., Feng, S., Ren, J., & Zhou, W. (2019). Upregulation of microRNA‐196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression. Journal of Cellular Biochemistry, 120(10), 17811-17821.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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