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Mouse Anti-LRP4 Recombinant Antibody (A936) (CBMAB-AP11501LY)

The product is antibody recognizes LRP4. The antibody A936 immunoassay techniques such as: ICC/IF, WB.
See all LRP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A936
Antibody Isotype
IgG1
Application
ICC/IF, WB

Basic Information

Immunogen
Fusion protein amino acids 1747-1905 (cytoplasmic C-terminus) of mouse LRP4
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LRP4
Entrez Gene ID
Human4038
Mouse228357
Rat83469
UniProt ID
HumanO75096
MouseQ8VI56
RatQ9QYP1
Alternative Names
Corin Antibody, KIAA0816 Antibody, LDLR Antibody, LDLR dan Antibody, Low density lipoprotein receptor related protein 4 Antibody, LRP-4 Antibody, LRP10 Antibody, MEGF7 Antibody, Multiple epidermal growth factor like domains 7 Antibody
Function
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).
Biological Process
Amyloid-beta clearance by cellular catabolic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Dendrite morphogenesisISS:UniProtKB
Dorsal/ventral pattern formationIEA:Ensembl
Embryonic digit morphogenesisIEA:Ensembl
EndocytosisIEA:UniProtKB-KW
Generation of neuronsManual Assertion Based On ExperimentIBA:GO_Central
Hair follicle developmentIEA:Ensembl
Kidney developmentManual Assertion Based On ExperimentIDA:UniProtKB
Limb developmentManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of axonogenesisISS:UniProtKB
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of ossificationManual Assertion Based On ExperimentIMP:UniProtKB
Odontogenesis of dentin-containing toothIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Positive regulation of presynaptic membrane organizationISS:UniProtKB
Positive regulation of skeletal muscle acetylcholine-gated channel clusteringIEA:Ensembl
Postsynaptic membrane assemblyISS:UniProtKB
Presynaptic membrane assemblyISS:UniProtKB
Proximal/distal pattern formationIEA:Ensembl
Skeletal muscle acetylcholine-gated channel clusteringISS:UniProtKB
Synapse organizationISS:UniProtKB
Synaptic assembly at neuromuscular junctionISS:UniProtKB
Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Cell membrane
Involvement in disease
Cenani-Lenz syndactyly syndrome (CLSS):
A congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs. It is characterized by fusion and disorganization of metacarpal and phalangeal bones, radius and ulnar shortening, radioulnar synostosis, and severe syndactyly of hands and feet.
Sclerosteosis 2 (SOST2):
A sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.
Myasthenic syndrome, congenital, 17 (CMS17):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort.
Topology
Extracellular: 21-1725
Helical: 1726-1746
Cytoplasmic: 1747-1905

Khan, H., Ullah, K., Jan, A., Ali, H., Ullah, I., & Ahmad, W. (2023). A variant in the LDL receptor‐related protein encoding gene LRP4 underlying polydactyly and phalangeal synostosis in a family of Pakistani origin. Congenital Anomalies, 63(6), 190-194.

Lagrange, J., Worou, M. E., Michel, J. B., Raoul, A., Didelot, M., Muczynski, V., ... & Regnault, V. (2022). The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells. Cardiovascular Research, 118(2), 622-637.

Cavieres-Lepe, J., & Stuardo, N. (2021). Amyloid β clearance is disrupted by depletion of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytes. Journal of Neuroscience, 41(17), 3749-3751.

Yan, M., Guo, A., Chen, P., Jing, H., Ren, D., Zhong, Y., ... & Wang, S. (2020). LRP4 LDLα repeats of astrocyte enhance dendrite arborization of the neuron. Molecular Brain, 13(1), 1-12.

Zhang, H., Chen, W., Tan, Z., Zhang, L., Dong, Z., Cui, W., ... & Mei, L. (2020). A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance. Journal of Neuroscience, 40(28), 5347-5361.

Lagrange, J., Michel, J. B., Raoul, A., Lenting, P., Lacolley, P., Denis, C., & Regnault, V. (2020). Von Willebrand Factor Induces Vascular Smooth Muscle Cell Proliferation and Migration Through Low Density Lipoprotein-Related Receptor Protein 4 and αvβ3 Integrin. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(Suppl_1), A304-A304.

Wang, J., Qiu, X., Xu, T., Sheng, Z., & Yao, L. (2019). Sclerostin/Receptor related protein 4 and ginkgo biloba extract alleviates β-glycerophosphate-induced vascular smooth muscle cell calcification by inhibiting Wnt/β-Catenin pathway. Blood Purification, 47(Suppl. 1), 17-23.

Li, M., Han, J., Zhang, Y., Lv, J., Zhang, J., Zhao, X., ... & Gao, F. (2019). Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis. European Journal of Neurology, 26(10), 1296-e84.

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For research use only. Not intended for any clinical use.

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