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Mouse Anti-LRRC4 Recombinant Antibody (CBYJL-2012) (CBMAB-L2117-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Containing 4 (LRRC4). The antibody can be used for immunoassay techniques, such as IHC.
See all LRRC4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2012
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human LRRC4, Ala39-Lys527, Accession # Q9HBW1.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine rich repeat containing 4
Introduction
LRRC4 is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.
Entrez Gene ID
64101
UniProt ID
Q9HBW1
Alternative Names
NAG14; NGL-2; leucine-rich repeat-containing protein 4; brain tumor associated protein LRRC4; brain tumor-associated protein BAG; nasopharyngeal carcinoma-associated gene 14 protein; netrin-G2 ligand
Function
Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).
Biological Process
Excitatory synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Postsynaptic density protein 95 clusteringManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Membrane
Cell junction, synapse, postsynaptic cell membrane
LRRC4 and DLG4 are interdependent for synaptic localization.
Topology
Extracellular: 39-527
Helical: 528-548
Cytoplasmic: 549-653
PTM
N-glycosylated.

Liu, Y., Xu, G., Fu, H., Li, P., Li, D., Deng, K., ... & Wu, M. (2023). Membrane-bound transcription factor LRRC4 inhibits glioblastoma cell motility. International Journal of Biological Macromolecules, 246, 125590.

Deng, K., & Wu, M. (2023). Leucine-rich repeats containing 4 protein (LRRC4) in memory, psychoneurosis, and glioblastoma. Chinese Medical Journal, 136(01), 4-12.

Zhang, Y., Li, D., Zeng, Q., Feng, J., Fu, H., Luo, Z., ... & Wu, M. (2021). LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis. Molecular Medicine, 27(1), 1-17.

Feng, J., Ren, X., Fu, H., Li, D., Chen, X., Zu, X., ... & Wu, M. (2021). LRRC4 mediates the formation of circular RNA CD44 to inhibit GBM cell proliferation. Molecular Therapy-Nucleic Acids, 26, 473-487.

Zhao, C., She, X., Zhang, Y., Liu, C., Li, P., Chen, S., ... & Wu, M. (2020). LRRC4 suppresses E-cadherin-dependent collective cell invasion and metastasis in epithelial ovarian cancer. Frontiers in Oncology, 10, 144.

Xue, Y., Xu, T., & Jiang, W. (2020). Dexmedetomidine protects PC12 cells from ropivacaine injury through miR-381/LRRC4/SDF-1/CXCR4 signaling pathway. Regenerative therapy, 14, 322-329.

Zhang, Y., Li, D., Zeng, Q., Feng, J., Fu, H., Luo, Z., ... & Wu, M. (2019). Deficiency of LRRC4 Accelerates Experimental Autoimmune Encephalomyelitis by Disrupting Th1/Treg Cell Balance.

Feng, J., Zhang, Y., Ren, X., Li, D., Fu, H., Liu, C., ... & Wu, M. (2019). LRRC4 Act As a Novel Autophagy Inhibitor that Restores Sensitivity of GBMs to Temozolomide. Available at SSRN 3432552.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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