LRRC4

LRRC4 is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.

Full Name

leucine rich repeat containing 4

Function

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).

Biological Process

Excitatory synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Postsynaptic density protein 95 clusteringManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cell junction, synapse, postsynaptic cell membrane
LRRC4 and DLG4 are interdependent for synaptic localization.

Topology

Extracellular: 39-527
Helical: 528-548
Cytoplasmic: 549-653

PTM

N-glycosylated.

Anti-LRRC4 antibodies

Mouse Anti-LRRC4 Recombinant Antibody (CBYJL-2012) (CBMAB-L2117-YJ)

Datasheet

SDS

Target: LRRC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-2012

Application*: IH

Mouse Anti-LRRC4 Recombinant Antibody (CBYJL-2013) (CBMAB-L2118-YJ)

Datasheet

SDS

Target: LRRC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBYJL-2013

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)