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LRRC4

LRRC4 is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.

Full Name

leucine rich repeat containing 4

Function

Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).

Biological Process

Excitatory synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Postsynaptic density protein 95 clusteringManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane
Cell junction, synapse, postsynaptic cell membrane
LRRC4 and DLG4 are interdependent for synaptic localization.

Topology

Extracellular: 39-527
Helical: 528-548
Cytoplasmic: 549-653

PTM

N-glycosylated.

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Anti-LRRC4 antibodies

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Mouse Anti-LRRC4 Recombinant Antibody (CBYJL-2013) (CBMAB-L2118-YJ)

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Target: LRRC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBYJL-2013

Application*: WB

Mouse Anti-LRRC4 Recombinant Antibody (CBYJL-2012) (CBMAB-L2117-YJ)

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Target: LRRC4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-2012

Application*: IH

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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