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Mouse Anti-LRRFIP1 Recombinant Antibody (CBYJL-2031) (CBMAB-L2146-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lrr Binding Flii Interacting Protein 1 (LRRFIP1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LRRFIP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2031
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
LRRFIP1 (AAH10662, 1 a.a. ~ 105 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MHVMDLQRDA NRQISDLKFK LAKSEQEITA LEQNVIRLES QVSRYKSAAE NAEKIEDELK AEKRKLQREL RSALDKTEEL EVSNGHLVKR LEKMKANRSA LLSQQ.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-105

Target

Full Name
LRRFIP1
Introduction
Diseases associated with LRRFIP1 include Gingival Recession. Among its related pathways are HIV Life Cycle and FGFR1 mutant receptor activation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and double-stranded RNA binding. An important paralog of this gene is LRRFIP2.
Entrez Gene ID
9208
UniProt ID
Q32MZ4
Alternative Names
GCF2; TRIP; FLAP1; GCF-2; FLAP-1; HUFI-1; FLIIAP1; leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; LRR FLII-interacting protein 1; NEDD8-conjugating enzyme; TAR RNA-interacting protein; leucine rich repeat (in FLII) interacting protein 1
Function
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Biological Process
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm

Chen, W., Zhao, W., Hao, M., & Wang, Y. (2023). lncRNA UCA1 regulates miR-132/Lrrfip1 axis to promote vascular smooth muscle cell proliferation. Open Medicine, 18(1), 20230738.

Wen, Y., Wang, E., Wang, X., Qing, S., Chaogetu, B., Wang, C., ... & Huang, Y. (2023). Copy number variations of LRRFIP1 gene and the relationship with growth traits in four Chinese sheep. Animal Biotechnology, 34(7), 3008-3015.

Ma, W., Bao, Z., Qian, Z., Zhang, K., Fan, W., Xu, J., ... & Jiang, T. (2022). LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma. CNS Neuroscience & Therapeutics, 28(6), 873-883.

Kawasaki, S., Ohtsuka, H., Sato, Y., Douchi, D., Sato, M., Ariake, K., ... & Unno, M. (2021). Silencing of LRRFIP1 enhances the sensitivity of gemcitabine in pancreatic cancer cells by activating JNK/c-Jun signaling. Pancreatology, 21(4), 771-778.

Liu, W., Duan, Q., Gong, L., Yang, Y., Huang, Z., Guo, H., & Niu, X. (2021). A novel LRRFIP1-ALK fusion in inflammatory myofibroblastic tumor of hip and response to crizotinib. Investigational New Drugs, 39, 278-282.

Yao, Y., Xu, K., Sun, Y., Tian, T., Shen, W., Sun, F., ... & Lei, M. (2020). MiR-215-5p inhibits the inflammation injury in septic H9c2 by regulating ILF3 and LRRFIP1. International Immunopharmacology, 78, 106000.

DeGregorio-Rocasolano, N., Guirao, V., Ponce, J., Melià-Sorolla, M., Aliena-Valero, A., García-Serran, A., ... & Gasull, T. (2020). Comparative proteomics unveils LRRFIP1 as a new player in the DAPK1 interactome of neurons exposed to oxygen and glucose deprivation. Antioxidants, 9(12), 1202.

Yin, X., Liu, P., Liu, Y. Y., Liu, M. Y., Fan, W. L., Liu, B. Y., & Zhao, J. H. (2019). LRRFIP1 expression triggers platelet agglutination by enhancing αIIbβ3 expression. Experimental and Therapeutic Medicine, 18(1), 269-277.

Takimoto, M. (2019). Multidisciplinary roles of LRRFIP1/GCF2 in human biological systems and diseases. Cells, 8(2), 108.

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For research use only. Not intended for any clinical use.

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