Mouse Anti-LRRTM1 Recombinant Antibody (5C3) (CBMAB-L2176-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1). The antibody can be used for immunoassay techniques, such as WB.
See all LRRTM1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

5C3

Antibody Isotype

IgG2a

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 182-422

Target

Full Name

Leucine Rich Repeat Transmembrane Neuronal 1

Introduction

Diseases associated with LRRTM1 include Schizophrenia. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. An important paralog of this gene is LRRTM2.Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

Entrez Gene ID

347730

UniProt ID

Q86UE6

Alternative Names

Leucine Rich Repeat Containing 4B; Netrin-G3 Ligand; Leucine-Rich Repeats And Immunoglobulin-Like Domains 4; LRIG4; NGL-3; Leucine-Rich Repeat-Containing Protein 4B; HSM

Function

Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.

Biological Process

Exploration behaviorIEA:Ensembl
Locomotory behaviorIEA:Ensembl
Long-term synaptic potentiationIEA:Ensembl
Negative regulation of receptor internalizationIEA:Ensembl
Positive regulation of synapse assemblyIEA:Ensembl
Protein localization to synapseIEA:Ensembl
Synapse organizationIEA:Ensembl

Cellular Location

Cell membrane
Cell junction, synapse, postsynaptic cell membrane

Topology

Extracellular: 35-427
Helical: 428-448
Cytoplasmic: 449-522

References

de Arce, K. P., Ribic, A., Chowdhury, D., Watters, K., Thompson, G. J., Sanganahalli, B. G., ... & Biederer, T. (2023). Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions. Nature Communications, 14(1), 459.

Karimi, B. (2022). Region-specific role of LRRTM1 in the organization of glutamatergic synapses in mediodorsal nucleus of the thalamus and hippocampal dorsal CA1 region.

Dhume, S. H., Connor, S. A., Mills, F., Tari, P. K., Au-Yeung, S. H., Karimi, B., ... & Siddiqui, T. J. (2022). Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits. Elife, 11, e64742.

Ban, D., Xiang, Z., Yu, P., & Liu, Y. (2022). Circular RNA hecw1 regulates the inflammatory imbalance in spinal cord injury via miR-3551-3p/LRRTM1 axis. Applied Biochemistry and Biotechnology, 194(11), 5151-5166.

Karimi, B., Silwal, P., Booth, S., Padmanabhan, N., Dhume, S. H., Zhang, D., ... & Siddiqui, T. J. (2021). Schizophrenia-associated LRRTM1 regulates cognitive behavior through controlling synaptic function in the mediodorsal thalamus. Molecular Psychiatry, 26(11), 6912-6925.

Zhang, L., Li, J., Li, Y., Wang, Z., Wang, G., Yu, Y., ... & Cui, W. (2020). Spinal caspase-3 contributes to tibial fracture-associated postoperative allodynia via up-regulation of LRRTM1 expression in mice. Neuroscience Letters, 739, 135429.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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