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Mouse Anti-LSM10 Recombinant Antibody (2522C1a) (CBMAB-L2197-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2522C1a
Antibody Isotype
IgG2a
Application
Dot, ICC

Basic Information

Immunogen
LSM10 antibody was raised in mouse using recombinant Human Lsm10, U7 Small Nuclear Rna Associated (Lsm10).
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LSM10, U7 small nuclear RNA associated
Introduction
Among its related pathways are Processing of Capped Intronless Pre-mRNA and Cleavage of Growing Transcript in the Termination Region. Gene Ontology (GO) annotations related to this gene include histone pre-mRNA DCP binding.It appears to function in the U7 snRNP complex that is involved in histone 3-end processing. LSM10 increases U7 snRNA levels but not histone 3-end pre-mRNA processing activity, when overexpressed. It is required for cell cycle progression from G1 to S phases. LSM10 binds specifically to U7 snRNA. LSM10 binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Entrez Gene ID
84967
UniProt ID
Q969L4
Alternative Names
LSM10, U7 Small Nuclear RNA Associated; U7 SnRNA-Associated Sm-Like Protein LSm10; U7 SnRNP-Specific Sm-Like Protein LSM10; MSTP074; MST074
Function
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Biological Process
mRNA 3'-end processing by stem-loop binding and cleavageManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus
PTM
Not methylated. Methylation is not necessary for interaction with SMN.
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For research use only. Not intended for any clinical use.

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