LSM10

LSM10 appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. LSM10 binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Full Name

LSM10, U7 small nuclear RNA associated

Function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Biological Process

mRNA 3'-end processing by stem-loop binding and cleavageManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus

PTM

Not methylated. Methylation is not necessary for interaction with SMN.

Anti-LSM10 antibodies

Mouse Anti-LSM10 Recombinant Antibody (CBYCL-504) (CBMAB-L0405-YC)

Datasheet

SDS

Target: LSM10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYCL-504

Application*: WB

Mouse Anti-LSM10 Recombinant Antibody (2522C1a) (CBMAB-L2197-YJ)

Datasheet

SDS

Target: LSM10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2522C1a

Application*: DB, IC

Mouse Anti-LSM10 Recombinant Antibody (CBYJL-2064) (CBMAB-L2198-YJ)

Datasheet

SDS

Target: LSM10

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-2064

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)