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LSM10

LSM10 appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. LSM10 binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Full Name

LSM10, U7 small nuclear RNA associated

Function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Biological Process

mRNA 3'-end processing by stem-loop binding and cleavageManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
RNA splicingIEA:UniProtKB-KW

Cellular Location

Nucleus

PTM

Not methylated. Methylation is not necessary for interaction with SMN.

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Anti-LSM10 antibodies

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Mouse Anti-LSM10 Recombinant Antibody (CBYCL-504) (CBMAB-L0405-YC)

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Target: LSM10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYCL-504

Application*: WB

Mouse Anti-LSM10 Recombinant Antibody (CBYJL-2064) (CBMAB-L2198-YJ)

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Target: LSM10

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-2064

Application*: WB

Mouse Anti-LSM10 Recombinant Antibody (2522C1a) (CBMAB-L2197-YJ)

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Target: LSM10

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2522C1a

Application*: DB, IC

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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