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Mouse Anti-LSM11 Recombinant Antibody (CBYJL-2066) (CBMAB-L2200-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lsm11 U7 Small Nuclear Rna Associated (LSM11). The antibody can be used for immunoassay techniques, such as WB.
See all LSM11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2066
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human LSM11(NP_775762) produced in E.coli.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LSM11, U7 small nuclear RNA associated
Introduction
Among its related pathways are Processing of Capped Intronless Pre-mRNA and Cleavage of Growing Transcript in the Termination Region. Gene Ontology (GO) annotations related to this gene include U7 snRNA binding.Component of the U7 snRNP complex that is involved in the histone 3-end pre-mRNA processing (By similarity). LSM11 increases U7 snRNA levels but not histone 3-end pre-mRNA processing activity, when overexpressed. It is required for cell cycle progression from G1 to S phases. LSM11 binds specifically to the Sm-binding site of U7 snRNA.
Entrez Gene ID
134353
UniProt ID
P83369
Alternative Names
LSM11, U7 Small Nuclear RNA Associated; LSM11 Homolog, U7 Small Nuclear RNA Associated (S. Cerevisiae); U7 SnRNA-Associated Sm-Like Protein LSm11
Function
Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297).
Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750).
Required for cell cycle progression from G1 to S phases (By similarity).
Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750).
Biological Process
mRNA 3'-end processing by stem-loop binding and cleavageManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chromatin organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Aicardi-Goutieres syndrome 8 (AGS8):
A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. AGS8 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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