Mouse Anti-LSM11 Recombinant Antibody (CBYJL-2070) (CBMAB-L2204-YJ)

Name: Mouse Anti-LSM11 Recombinant Antibody (CBYJL-2070)
SKU: CBMAB-L2204-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-2070

Application

WB, IHC

Immunogen

Full length human recombinant protein of human LSM11(NP_775762) produced in E.coli.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LSM11, U7 small nuclear RNA associated

Introduction

Among its related pathways are Processing of Capped Intronless Pre-mRNA and Cleavage of Growing Transcript in the Termination Region. Gene Ontology (GO) annotations related to this gene include U7 snRNA binding.Component of the U7 snRNP complex that is involved in the histone 3-end pre-mRNA processing (By similarity). LSM11 increases U7 snRNA levels but not histone 3-end pre-mRNA processing activity, when overexpressed. It is required for cell cycle progression from G1 to S phases. LSM11 binds specifically to the Sm-binding site of U7 snRNA.

Entrez Gene ID

134353

UniProt ID

P83369

Alternative Names

LSM11, U7 Small Nuclear RNA Associated; LSM11 Homolog, U7 Small Nuclear RNA Associated (S. Cerevisiae); U7 SnRNA-Associated Sm-Like Protein LSm11

Function

Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:11574479, PubMed:16914750, PubMed:33230297).
Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:11574479, PubMed:16914750).
Required for cell cycle progression from G1 to S phases (By similarity).
Binds specifically to the Sm-binding site of U7 snRNA (PubMed:11574479, PubMed:16914750).

Biological Process

mRNA 3'-end processing by stem-loop binding and cleavageManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chromatin organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus

Involvement in disease

Aicardi-Goutieres syndrome 8 (AGS8):
A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. AGS8 inheritance is autosomal recessive.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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