Mouse Anti-LSM14A Recombinant Antibody (C-5) (CBMAB-R0580-CN)

This product is a Mouse antibody that recognizes LSM14A. The antibody C-5 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all LSM14A antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

C-5

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name

LSM14A, mRNA processing body assembly factor

Introduction

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. The Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]

Entrez Gene ID

Human	26065
Mouse	67070
Rat	361554

UniProt ID

Human	Q8ND56
Mouse	Q8K2F8
Rat	B2GV58

Alternative Names

RAP55; FAM61A; RAP55A; C19orf13

Function

Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985).
Acts as a repressor of mRNA translation (PubMed:29510985).
May play a role in mitotic spindle assembly (PubMed:26339800).

Biological Process

Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of translationManual Assertion Based On ExperimentIMP:UniProtKB
P-body assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of type I interferon-mediated signaling pathwayIEA:Ensembl
RIG-I signaling pathwayIEA:Ensembl
Stress granule assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, P-body
Cytoplasm, cytoskeleton, spindle
Cytoplasm, Stress granule

References

Ngo, C., Verret, B., Vibert, J., Cotteret, S., Levy, A., Pechoux, C. L., ... & Pierron, G. (2023). A novel fusion variant LSM14A:: NR4A3 in extraskeletal myxoid chondrosarcoma. Genes, Chromosomes and Cancer, 62(1), 52-56.

Zhang, L., Fu, Y., Zhang, R., Guan, Y., Jiang, N., Zheng, N., & Wu, Z. (2021). Nonstructural protein NSs hampers cellular antiviral response through lsm14a during severe fever with thrombocytopenia syndrome virus infection. The Journal of Immunology, 207(2), 590-601.

Zhang, T. R., & Huang, W. (2021). Circ-0010928 Negatively Regulates Hypoxia-Induced Endothelial Cell Angiogenesis Through The miR-921/LSM14A axis.

Lv, Y., Ling, F., Zhang, J., Xiao, M., & Mao, W. (2020). A novel intergenic LSM14A-RET fusion variant in a patient with lung adenocarcinoma. Journal of Thoracic Oncology, 15(4), e52-e53.

Tian, L., Wu, C., Wen, G., & Li, C. (2019). Transcriptional responses of LSm14A after infection of blue eggshell layers with Newcastle disease viruses. Journal of Veterinary Medical Science, 81(10), 1468-1474.

Murakami, S., Morimoto, N., Kono, T., Sakai, M., & Hikima, J. I. (2019). Molecular characterization and expression of the teleost cytosolic DNA sensor genes cGAS, LSm14A, DHX9, and DHX36 in Japanese medaka, Oryzias latipes. Developmental & Comparative Immunology, 99, 103402.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-LSM14A Recombinant Antibody (G-5)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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