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Mouse Anti-LSM3 Recombinant Antibody (4C8-2D10) (CBMAB-L2216-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lsm3 Homolog U6 Small Nuclear Rna And Mrna Degradation Associated (LSM3). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all LSM3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C8-2D10
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa 1-103 from human LSM3 (AAH07055) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-103

Target

Full Name
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Introduction
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins contain the Sm sequence motif, which composed of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.It binds specifically to the 3'-terminal U-tract of U6 snRNA.
Entrez Gene ID
27258
UniProt ID
P62310
Alternative Names
SMX4; USS2; YLR438C; U6 snRNA-associated Sm-like protein LSm3; LSM3 U6 small nuclear RNA and mRNA degradation associated; LSM3 homolog, U6 small nuclear RNA associated
Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
Biological Process
mRNA processingManual Assertion Based On ExperimentTAS:UniProtKB
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
P-body assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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