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LSM3

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM

Full Name

LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).

Biological Process

mRNA processingManual Assertion Based On ExperimentTAS:UniProtKB
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
P-body assemblyManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

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Anti-LSM3 antibodies

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Human Recombinant LSM3 protein, His Tag (V2LY-0526-LY5392)

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Target: LSM3

Expressed Host: E. coli

Sequence: Amino Acid: 1-102

Tag: His Tag

Mouse Anti-LSM3 Recombinant Antibody (4H3) (CBMAB-A5087-LY)

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Target: LSM3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H3

Application*: WB, E

Mouse Anti-LSM3 Recombinant Antibody (CBYCL-505) (CBMAB-L0406-YC)

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Target: LSM3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYCL-505

Application*: E, WB

Mouse Anti-LSM3 Recombinant Antibody (CBYJL-2080) (CBMAB-L2217-YJ)

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Target: LSM3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-2080

Application*: E, WB

Mouse Anti-LSM3 Recombinant Antibody (4C8-2D10) (CBMAB-L2216-YJ)

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Target: LSM3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C8-2D10

Application*: E, IF, WB

Mouse Anti-LSM3 Recombinant Antibody (CBYJL-2079) (CBMAB-L2215-YJ)

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Target: LSM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-2079

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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