Rabbit Anti-LTA Recombinant Antibody (
3G11) (V2LY-0725-LY809)

Name: Rabbit Anti-LTA Recombinant Antibody (3G11)
SKU: V2LY-0725-LY809
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

3G11

Application

ELISA

Immunogen

A synthesized peptide derived from human LTA.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LTA

Entrez Gene ID

4049

UniProt ID

P01374

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508).
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Humoral immune responseIEA:Ensembl
Lymph node developmentIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of chronic inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Positive regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Positive regulation of interferon-gamma productionIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nutrientIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.

Involvement in disease

Psoriatic arthritis (PSORAS):
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

Alhelf, M., Shoaib, R. M., Elsaid, A., Bastawy, N., Elbeltagy, N. S., Salem, E. T., ... & Abuelnadar, E. H. (2023). Prognostic significance of the genetic variant of lymphotoxin alpha (p. Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. Molecular Biology Reports, 50(5), 4317-4327.

Huang, J. F., Li, H., Li, L., Xiao, A. Y., Liao, C., & Li, Y. (2023). Significantly reduced level of lymphotoxin-alpha (LTA) in tears from dry eye patients with Sjogren’s syndrome or other systemic immune disease detected with a Point-of-Care LTA test. Investigative Ophthalmology & Visual Science, 64(8), 3946-3946.

Sailliet, N., Mai, H. L., Dupuy, A., Tilly, G., Fourgeux, C., Braud, M., ... & Brouard, S. (2023). Human granzyme B regulatory B cells prevent effector CD4+ CD25-T cell proliferation through a mechanism dependent from lymphotoxin alpha. Frontiers in Immunology, 14.

Mohammed, S. O., Utba, N. M., & Raof, Y. S. (2022). Lymphotoxin alpha gene expression in Iraqi breast cancer women. Biomedicine, 42(6), 1323-1326.

Werner, F., Wagner, C., Simon, M., Glatz, K., Mertz, K. D., Läubli, H., ... & Wagner, S. N. (2021). Loss of lymphotoxin alpha-expressing memory B cells correlates with metastasis of human primary melanoma. Diagnostics, 11(7), 1238.

Galal, G., Tammam, H., Abdel Aal, A., Fahmy, N., Sheneef, A., Ahmed, N., & Zaghloul, A. (2021). Role of Lymphotoxin-α gene polymorphism in hepatitis C virus-related chronic liver disorders. Infection and Drug Resistance, 1921-1930.

Guo, S., Zuo, Q., Li, X., He, Y., & Zhou, Y. (2020). Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis. BioMed research international, 2020.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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