LTA
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis
Full Name
LTA
Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508).
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Humoral immune responseIEA:Ensembl
Lymph node developmentIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of chronic inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Positive regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Positive regulation of interferon-gamma productionIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nutrientIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Humoral immune responseIEA:Ensembl
Lymph node developmentIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of chronic inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Positive regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Positive regulation of interferon-gamma productionIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nutrientIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.
Involvement in disease
Psoriatic arthritis (PSORAS):
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
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Anti-LTA antibodies
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CompareTarget: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A946
Application*: WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: A945
Application*: Dot blot, ELISA, IF, WB
Target: LTA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-082
Application*: E
Target: LTA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3G11
Application*: E
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B5
Application*: WB, E
Target: LTA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E1
Application*: WB, E
Target: Lta
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-1430
Application*: WB
Target: LTA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-1429
Application*: WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYJT-1428
Application*: WB, E, P, IC, IF
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-1427
Application*: IC, IH, N, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1426
Application*: E, C
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1425
Application*: E, F, IH, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-1424
Application*: F, IF, N, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1423
Application*: ED, N
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1422
Application*: F
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYCL-637
Application*: E, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCL-523
Application*: WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-522
Application*: WB, IC, P, C, E
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-521
Application*: WB, IC, P, C, E
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCL-520
Application*: F, FN, N, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-519
Application*: E, F, N, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBYCL-518
Application*: WB, E
Target: Lta
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYJL-2414
Application*: WB
Target: LTA
Host: Rat
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJL-2133
Application*: WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0575-7U9
Application*: P, N
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0460-12B4
Application*: N, F
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-2132
Application*: WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: AT15A3
Application*: E, WB, IF
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2131
Application*: IH, N, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6D85
Application*: FC, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2130
Application*: IS
Target: LTA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJL-2129
Application*: N, EC
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5802
Application*: N, IC
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 359-81-11
Application*: E, F, N
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2119
Application*: EC
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-2102
Application*: E, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 15A3
Application*: WB, E, IC, IF
Target: LTA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-2101
Application*: E
Target: LTA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 10K401
Application*: E, IF, WB
Target: LTA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2098
Application*: N
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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