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Mouse Anti-LTA Recombinant Antibody (CBYJT-1422) (CBMAB-T0446-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to LTA (Lymphotoxin Alpha). The antibody can be used for immunoassay techniques, such as FC.
See all LTA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1422
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 0.1% Gelatin
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LTA
Introduction
LTA is a cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Entrez Gene ID
UniProt ID
Alternative Names
LT; TNFB; TNFSF1; TNLG1E
Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508).
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Humoral immune responseIEA:Ensembl
Lymph node developmentIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of chronic inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Positive regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Positive regulation of interferon-gamma productionIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nutrientIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.
Involvement in disease
Psoriatic arthritis (PSORAS):
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

Alhelf, M., Shoaib, R. M., Elsaid, A., Bastawy, N., Elbeltagy, N. S., Salem, E. T., ... & Abuelnadar, E. H. (2023). Prognostic significance of the genetic variant of lymphotoxin alpha (p. Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. Molecular Biology Reports, 50(5), 4317-4327.

Huang, J. F., Li, H., Li, L., Xiao, A. Y., Liao, C., & Li, Y. (2023). Significantly reduced level of lymphotoxin-alpha (LTA) in tears from dry eye patients with Sjogren’s syndrome or other systemic immune disease detected with a Point-of-Care LTA test. Investigative Ophthalmology & Visual Science, 64(8), 3946-3946.

Sailliet, N., Mai, H. L., Dupuy, A., Tilly, G., Fourgeux, C., Braud, M., ... & Brouard, S. (2023). Human granzyme B regulatory B cells prevent effector CD4+ CD25-T cell proliferation through a mechanism dependent from lymphotoxin alpha. Frontiers in Immunology, 14.

Mohammed, S. O., Utba, N. M., & Raof, Y. S. (2022). Lymphotoxin alpha gene expression in Iraqi breast cancer women. Biomedicine, 42(6), 1323-1326.

Werner, F., Wagner, C., Simon, M., Glatz, K., Mertz, K. D., Läubli, H., ... & Wagner, S. N. (2021). Loss of lymphotoxin alpha-expressing memory B cells correlates with metastasis of human primary melanoma. Diagnostics, 11(7), 1238.

Galal, G., Tammam, H., Abdel Aal, A., Fahmy, N., Sheneef, A., Ahmed, N., & Zaghloul, A. (2021). Role of Lymphotoxin-α gene polymorphism in hepatitis C virus-related chronic liver disorders. Infection and Drug Resistance, 1921-1930.

Guo, S., Zuo, Q., Li, X., He, Y., & Zhou, Y. (2020). Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis. BioMed research international, 2020.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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