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Mouse Anti-LTA Recombinant Antibody (CBYCL-523) (CBMAB-L0424-YC)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBYCL-523
Application
WB
Immunogen
A synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of LT-alpha
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.05% sodium azide, 0.5% BSA, 25% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus
More Infomation

Target

Full Name
LTA
Introduction
LTA is a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis.
Entrez Gene ID
Human4049
Mouse16992
Rat25008
UniProt ID
HumanP01374
MouseP09225
RatQ06332
Alternative Names
LT; TNFB; TNFSF1; TNLG1E
Function
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508).
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Humoral immune responseIEA:Ensembl
Lymph node developmentIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of chronic inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Positive regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Positive regulation of interferon-gamma productionIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nutrientIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.
Involvement in disease
Psoriatic arthritis (PSORAS):
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

Alhelf, M., Shoaib, R. M., Elsaid, A., Bastawy, N., Elbeltagy, N. S., Salem, E. T., ... & Abuelnadar, E. H. (2023). Prognostic significance of the genetic variant of lymphotoxin alpha (p. Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. Molecular Biology Reports, 50(5), 4317-4327.

Huang, J. F., Li, H., Li, L., Xiao, A. Y., Liao, C., & Li, Y. (2023). Significantly reduced level of lymphotoxin-alpha (LTA) in tears from dry eye patients with Sjogren’s syndrome or other systemic immune disease detected with a Point-of-Care LTA test. Investigative Ophthalmology & Visual Science, 64(8), 3946-3946.

Sailliet, N., Mai, H. L., Dupuy, A., Tilly, G., Fourgeux, C., Braud, M., ... & Brouard, S. (2023). Human granzyme B regulatory B cells prevent effector CD4+ CD25-T cell proliferation through a mechanism dependent from lymphotoxin alpha. Frontiers in Immunology, 14.

Mohammed, S. O., Utba, N. M., & Raof, Y. S. (2022). Lymphotoxin alpha gene expression in Iraqi breast cancer women. Biomedicine, 42(6), 1323-1326.

Werner, F., Wagner, C., Simon, M., Glatz, K., Mertz, K. D., Läubli, H., ... & Wagner, S. N. (2021). Loss of lymphotoxin alpha-expressing memory B cells correlates with metastasis of human primary melanoma. Diagnostics, 11(7), 1238.

Galal, G., Tammam, H., Abdel Aal, A., Fahmy, N., Sheneef, A., Ahmed, N., & Zaghloul, A. (2021). Role of Lymphotoxin-α gene polymorphism in hepatitis C virus-related chronic liver disorders. Infection and Drug Resistance, 1921-1930.

Guo, S., Zuo, Q., Li, X., He, Y., & Zhou, Y. (2020). Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis. BioMed research international, 2020.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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