Human Recombinant LTA protein (V2LY-0526-LY5403)

Name: Human Recombinant LTA protein
SKU: V2LY-0526-LY5403
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant LTA protein consist of Amino Acid: 35-205 and predicts a molecular mass of 18.8 kDa.

Molecule Mass

18.8 kDa

Sequence

Amino Acid: 35-205

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE, ≥ 85% as determined by SEC-MALS(Routinely tested).

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

LTA

Function

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508).
In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Humoral immune responseIEA:Ensembl
Lymph node developmentIEA:Ensembl
Negative regulation of fibroblast proliferationIEA:Ensembl
Positive regulation of apoptotic processIEA:Ensembl
Positive regulation of chronic inflammatory response to antigenic stimulusIEA:Ensembl
Positive regulation of glial cell proliferationIEA:Ensembl
Positive regulation of humoral immune response mediated by circulating immunoglobulinIEA:Ensembl
Positive regulation of interferon-gamma productionIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to nutrientIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Secreted
Membrane
The homotrimer is secreted. The heterotrimer is membrane-associated.

Involvement in disease

Psoriatic arthritis (PSORAS):
An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).

Alhelf, M., Shoaib, R. M., Elsaid, A., Bastawy, N., Elbeltagy, N. S., Salem, E. T., ... & Abuelnadar, E. H. (2023). Prognostic significance of the genetic variant of lymphotoxin alpha (p. Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. Molecular Biology Reports, 50(5), 4317-4327.

Huang, J. F., Li, H., Li, L., Xiao, A. Y., Liao, C., & Li, Y. (2023). Significantly reduced level of lymphotoxin-alpha (LTA) in tears from dry eye patients with Sjogren’s syndrome or other systemic immune disease detected with a Point-of-Care LTA test. Investigative Ophthalmology & Visual Science, 64(8), 3946-3946.

Sailliet, N., Mai, H. L., Dupuy, A., Tilly, G., Fourgeux, C., Braud, M., ... & Brouard, S. (2023). Human granzyme B regulatory B cells prevent effector CD4+ CD25-T cell proliferation through a mechanism dependent from lymphotoxin alpha. Frontiers in Immunology, 14.

Mohammed, S. O., Utba, N. M., & Raof, Y. S. (2022). Lymphotoxin alpha gene expression in Iraqi breast cancer women. Biomedicine, 42(6), 1323-1326.

Werner, F., Wagner, C., Simon, M., Glatz, K., Mertz, K. D., Läubli, H., ... & Wagner, S. N. (2021). Loss of lymphotoxin alpha-expressing memory B cells correlates with metastasis of human primary melanoma. Diagnostics, 11(7), 1238.

Galal, G., Tammam, H., Abdel Aal, A., Fahmy, N., Sheneef, A., Ahmed, N., & Zaghloul, A. (2021). Role of Lymphotoxin-α gene polymorphism in hepatitis C virus-related chronic liver disorders. Infection and Drug Resistance, 1921-1930.

Guo, S., Zuo, Q., Li, X., He, Y., & Zhou, Y. (2020). Association between the Lymphotoxin-α A252g Gene Polymorphism and the Risk of Sepsis and Mortality: A Meta-Analysis. BioMed research international, 2020.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LTA & LTB protein, Flag & His Tag (CAT#: V2LY-0526-LY5404)

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Isotype control

For research use only. Not intended for any clinical use.

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