Rabbit Anti-LTA4H Recombinant Antibody (
6G7) (V2LY-0725-LY1035)

Name: Rabbit Anti-LTA4H Recombinant Antibody (6G7)
SKU: V2LY-0725-LY1035
Rating: 5 (1 reviews)

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Tested Data

Rabbit Anti-LTA4H Recombinant Antibody (6G7) (V2LY-0725-LY1035) in WB

Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, 293T whole cell lysate, PC-3 whole cell lysate, Mouse Brain whole cell lysate
All lanes: LTA4H antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70, 60, 58, 67 kDa
Observed band size: 70 kDa

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

6G7

Application

ELISA, WB

Immunogen

A synthesized peptide derived from human LTA4H.

Host Species

Rabbit

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, glycerol

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

leukotriene A4 hydrolase

Entrez Gene ID

4048

UniProt ID

P09960

Function

Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921).
Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029).
In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641).
Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).

Biological Process

Cellular protein metabolic processManual Assertion Based On ExperimentIMP:CAFA
Leukotriene biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Lipid metabolic processIEA:UniProtKB-KW
Peptide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to peptide hormoneIEA:Ensembl
Response to zinc ionIEA:Ensembl
Type I pneumocyte differentiationIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity.

Ren, T., Wang, S., Zhang, B., Zhou, W., Wang, C., Zhao, X., & Feng, J. (2023). LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets. PeerJ, 11, e14875.

Wan, X., Wang, H., Shi, B., Guo, Y., Liu, S. Y., & Wang, X. (2023). An enzyme activated fluorescent probe for LTA4H activity sensing and its application in cancer screening. Talanta, 253, 123887.

Kumar, S. S., Solomon, R., Gautam, P., Inbaraj, L. R., Sivadasan, A., Michael, J. S., ... & Manesh, A. (2023). Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis. Scientific Reports, 13(1), 3746.

Fenanir, F., Semmeq, A., Benguerba, Y., Badawi, M., Dziurla, M. A., Amira, S., & Laouer, H. (2022). In silico investigations of some Cyperus rotundus compounds as potential anti-inflammatory inhibitors of 5-LO and LTA4H enzymes. Journal of Biomolecular Structure and Dynamics, 40(22), 11571-11586.

Siddiqi, O. K., Ghebremichael, M., Musukuma, K., Dang, X., Mubanga, E., Birbeck, G. L., ... & Koralnik, I. J. (2021). LTA4H prevalence and mortality in adult Zambians with tuberculous meningitis. Annals of neurology, 90(6), 994-998.

Qin, R., Wang, H., & Yan, A. (2021). Classification and QSAR models of leukotriene A4 hydrolase (LTA4H) inhibitors by machine learning methods. SAR and QSAR in Environmental Research, 32(5), 411-431.

Maroteau, C., Espuela-Ortiz, A., Herrera-Luis, E., Srinivasan, S., Carr, F., Tavendale, R., ... & PiCA Consortium. (2021). LTA4H rs2660845 association with montelukast response in early and late-onset asthma. Plos one, 16(9), e0257396.

Wang, H., Xue, K., Duan, Z., Yang, Y., He, Z., Wu, C., ... & Tang, B. (2019). A photoacoustic and fluorescence dual-mode probe for LTA4H imaging reveals inflammation site in murine. Sensors and Actuators B: Chemical, 286, 243-249.

Zhao, S., Yao, K., Li, D., Liu, K., Jin, G., Yan, M., ... & Dong, Z. (2019). Inhibition of LTA4H by bestatin in human and mouse colorectal cancer. EBioMedicine, 44, 361-374.

Gao, W., An, C., Xue, X., Zheng, X., Niu, M., Zhang, Y., ... & Wang, B. (2019). Mass spectrometric analysis identifies AIMP1 and LTA4H as FSCN1‐binding proteins in laryngeal squamous cell carcinoma. Proteomics, 19(21-22), 1900059.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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