Mouse Lta4h ELISA Kit (V2LY-0626-LY1791)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.027 ng/mL
Detection Range
0.05-15 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
69.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
leukotriene A4 hydrolase
Function
Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921).
Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029).
In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641).
Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).
Biological Process
Cellular protein metabolic processManual Assertion Based On ExperimentIMP:CAFA
Leukotriene biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Lipid metabolic processIEA:UniProtKB-KW
Peptide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to peptide hormoneIEA:Ensembl
Response to zinc ionIEA:Ensembl
Type I pneumocyte differentiationIEA:Ensembl
Cellular Location
Cytoplasm
PTM
Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity.

Ren, T., Wang, S., Zhang, B., Zhou, W., Wang, C., Zhao, X., & Feng, J. (2023). LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets. PeerJ, 11, e14875.

Wan, X., Wang, H., Shi, B., Guo, Y., Liu, S. Y., & Wang, X. (2023). An enzyme activated fluorescent probe for LTA4H activity sensing and its application in cancer screening. Talanta, 253, 123887.

Kumar, S. S., Solomon, R., Gautam, P., Inbaraj, L. R., Sivadasan, A., Michael, J. S., ... & Manesh, A. (2023). Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis. Scientific Reports, 13(1), 3746.

Fenanir, F., Semmeq, A., Benguerba, Y., Badawi, M., Dziurla, M. A., Amira, S., & Laouer, H. (2022). In silico investigations of some Cyperus rotundus compounds as potential anti-inflammatory inhibitors of 5-LO and LTA4H enzymes. Journal of Biomolecular Structure and Dynamics, 40(22), 11571-11586.

Siddiqi, O. K., Ghebremichael, M., Musukuma, K., Dang, X., Mubanga, E., Birbeck, G. L., ... & Koralnik, I. J. (2021). LTA4H prevalence and mortality in adult Zambians with tuberculous meningitis. Annals of neurology, 90(6), 994-998.

Qin, R., Wang, H., & Yan, A. (2021). Classification and QSAR models of leukotriene A4 hydrolase (LTA4H) inhibitors by machine learning methods. SAR and QSAR in Environmental Research, 32(5), 411-431.

Maroteau, C., Espuela-Ortiz, A., Herrera-Luis, E., Srinivasan, S., Carr, F., Tavendale, R., ... & PiCA Consortium. (2021). LTA4H rs2660845 association with montelukast response in early and late-onset asthma. Plos one, 16(9), e0257396.

Wang, H., Xue, K., Duan, Z., Yang, Y., He, Z., Wu, C., ... & Tang, B. (2019). A photoacoustic and fluorescence dual-mode probe for LTA4H imaging reveals inflammation site in murine. Sensors and Actuators B: Chemical, 286, 243-249.

Zhao, S., Yao, K., Li, D., Liu, K., Jin, G., Yan, M., ... & Dong, Z. (2019). Inhibition of LTA4H by bestatin in human and mouse colorectal cancer. EBioMedicine, 44, 361-374.

Gao, W., An, C., Xue, X., Zheng, X., Niu, M., Zhang, Y., ... & Wang, B. (2019). Mass spectrometric analysis identifies AIMP1 and LTA4H as FSCN1‐binding proteins in laryngeal squamous cell carcinoma. Proteomics, 19(21-22), 1900059.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant LTA4H protein, His Tag (CAT#: V2LY-0526-LY5287)

Mouse Recombinant LTA4H protein, His Tag (CAT#: V2LY-0526-LY8615)

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Human Recombinant LTA4H protein, His Tag (CAT#: V2LY-0526-LY5287)

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For research use only. Not intended for any clinical use.

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