Mouse Anti-LTA4H Recombinant Antibody (6B5) (CBMAB-L2297-YJ)

Name: Mouse Anti-LTA4H Recombinant Antibody (6B5)
SKU: CBMAB-L2297-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6B5

Application

FC, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

leukotriene A4 hydrolase

Introduction

LTA4H is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been observed for this gene.

Entrez Gene ID

4048

UniProt ID

P09960

Alternative Names

leukotriene A-4 hydrolase; LTA-4 hydrolase; testicular secretory protein Li 27; EC 3.3.2.6

Function

Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921).
Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029).
In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641).
Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090).

Biological Process

Cellular protein metabolic processManual Assertion Based On ExperimentIMP:CAFA
Leukotriene biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Lipid metabolic processIEA:UniProtKB-KW
Peptide catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to peptide hormoneIEA:Ensembl
Response to zinc ionIEA:Ensembl
Type I pneumocyte differentiationIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity.

Ren, T., Wang, S., Zhang, B., Zhou, W., Wang, C., Zhao, X., & Feng, J. (2023). LTA4H extensively associates with mRNAs and lncRNAs indicative of its novel regulatory targets. PeerJ, 11, e14875.

Wan, X., Wang, H., Shi, B., Guo, Y., Liu, S. Y., & Wang, X. (2023). An enzyme activated fluorescent probe for LTA4H activity sensing and its application in cancer screening. Talanta, 253, 123887.

Kumar, S. S., Solomon, R., Gautam, P., Inbaraj, L. R., Sivadasan, A., Michael, J. S., ... & Manesh, A. (2023). Leukotriene A4 hydrolase (LTA4H rs17525495) gene polymorphisms and paradoxical reactions in extrapulmonary tuberculosis. Scientific Reports, 13(1), 3746.

Fenanir, F., Semmeq, A., Benguerba, Y., Badawi, M., Dziurla, M. A., Amira, S., & Laouer, H. (2022). In silico investigations of some Cyperus rotundus compounds as potential anti-inflammatory inhibitors of 5-LO and LTA4H enzymes. Journal of Biomolecular Structure and Dynamics, 40(22), 11571-11586.

Siddiqi, O. K., Ghebremichael, M., Musukuma, K., Dang, X., Mubanga, E., Birbeck, G. L., ... & Koralnik, I. J. (2021). LTA4H prevalence and mortality in adult Zambians with tuberculous meningitis. Annals of neurology, 90(6), 994-998.

Qin, R., Wang, H., & Yan, A. (2021). Classification and QSAR models of leukotriene A4 hydrolase (LTA4H) inhibitors by machine learning methods. SAR and QSAR in Environmental Research, 32(5), 411-431.

Maroteau, C., Espuela-Ortiz, A., Herrera-Luis, E., Srinivasan, S., Carr, F., Tavendale, R., ... & PiCA Consortium. (2021). LTA4H rs2660845 association with montelukast response in early and late-onset asthma. Plos one, 16(9), e0257396.

Wang, H., Xue, K., Duan, Z., Yang, Y., He, Z., Wu, C., ... & Tang, B. (2019). A photoacoustic and fluorescence dual-mode probe for LTA4H imaging reveals inflammation site in murine. Sensors and Actuators B: Chemical, 286, 243-249.

Zhao, S., Yao, K., Li, D., Liu, K., Jin, G., Yan, M., ... & Dong, Z. (2019). Inhibition of LTA4H by bestatin in human and mouse colorectal cancer. EBioMedicine, 44, 361-374.

Gao, W., An, C., Xue, X., Zheng, X., Niu, M., Zhang, Y., ... & Wang, B. (2019). Mass spectrometric analysis identifies AIMP1 and LTA4H as FSCN1‐binding proteins in laryngeal squamous cell carcinoma. Proteomics, 19(21-22), 1900059.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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