Mouse Anti-LTBR Recombinant Antibody (7E3) (CBMAB-A5120-LY)

Name: Mouse Anti-LTBR Recombinant Antibody (7E3)
SKU: CBMAB-A5120-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

7E3

Application

ELISA

Immunogen

LTBR (NP_002333.1, 37 a.a. ~ 225 a.a) partial recombinant protein.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LTBR

Introduction

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. [provided by RefSeq]

Entrez Gene ID

4055

UniProt ID

P36941

Alternative Names

D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3

Function

Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Immune responseIEA:InterPro
Myeloid dendritic cell differentiationIEA:Ensembl
Positive regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Membrane

Topology

Extracellular: 31-227
Helical: 228-248
Cytoplasmic: 249-435

Miki, H., Kiosses, W. B., Manresa, M. C., Gupta, R. K., Sethi, G. S., Herro, R., ... & Croft, M. (2023). Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. Journal of Allergy and Clinical Immunology, 151(4), 976-990.

Saxena, V., Piao, W., Li, L., Paluskievicz, C., Xiong, Y., Simon, T., ... & Bromberg, J. S. (2022). Treg tissue stability depends on lymphotoxin beta-receptor-and adenosine-receptor-driven lymphatic endothelial cell responses. Cell reports, 39(3).

Legut, M., Guarino, M., Xue, X., Lu, C., Vyas, R., Diefenbach, C. S., & Sanjana, N. (2022). Preclinical Development of Lymphotoxin Beta Receptor-Overexpressing CAR T Cells Demonstrates Potentiation of CAR T Cell Antitumor Activity. Blood, 140(Supplement 1), 10235-10236.

Chen, Y. G. (2022). Investigating the role of the linear ubiquitin chain assembly complex in lymphotoxin beta receptor signalling and obesity-derived hepatitis (Doctoral dissertation, UCL (University College London)).

Shou, Y., Koroleva, E., Spencer, C. M., Shein, S. A., Korchagina, A. A., Yusoof, K. A., ... & Tumanov, A. V. (2021). Redefining the role of lymphotoxin beta receptor in the maintenance of lymphoid organs and immune cell homeostasis in adulthood. Frontiers in immunology, 12, 712632.

Francipane, M. G., Han, B., & Lagasse, E. (2020). Host lymphotoxin-β receptor signaling is crucial for angiogenesis of metanephric tissue transplanted into lymphoid sites. The American Journal of Pathology, 190(1), 252-269.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

LTBR Matched Antibody Pair (700) (CAT#: APMAB-700LY)

LTBR Matched Antibody Pair (701) (CAT#: APMAB-701LY)

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Isotype control

For research use only. Not intended for any clinical use.

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