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Mouse Anti-LTBR Recombinant Antibody (7E3) (CBMAB-A5120-LY)

The product is antibody recognizes LTBR. The antibody 7E3 immunoassay techniques such as: ELISA.
See all LTBR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7E3
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
LTBR (NP_002333.1, 37 a.a. ~ 225 a.a) partial recombinant protein.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LTBR
Introduction
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. [provided by RefSeq]
Entrez Gene ID
4055
UniProt ID
P36941
Alternative Names
D12S370; LT-BETA-R; TNF-R-III; TNFCR; TNFR-RP; TNFR2-RP; TNFRSF3
Function
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cellular response to mechanical stimulusManual Assertion Based On ExperimentIEP:UniProtKB
Immune responseIEA:InterPro
Myeloid dendritic cell differentiationIEA:Ensembl
Positive regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of JNK cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 31-227
Helical: 228-248
Cytoplasmic: 249-435

Miki, H., Kiosses, W. B., Manresa, M. C., Gupta, R. K., Sethi, G. S., Herro, R., ... & Croft, M. (2023). Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction. Journal of Allergy and Clinical Immunology, 151(4), 976-990.

Saxena, V., Piao, W., Li, L., Paluskievicz, C., Xiong, Y., Simon, T., ... & Bromberg, J. S. (2022). Treg tissue stability depends on lymphotoxin beta-receptor-and adenosine-receptor-driven lymphatic endothelial cell responses. Cell reports, 39(3).

Legut, M., Guarino, M., Xue, X., Lu, C., Vyas, R., Diefenbach, C. S., & Sanjana, N. (2022). Preclinical Development of Lymphotoxin Beta Receptor-Overexpressing CAR T Cells Demonstrates Potentiation of CAR T Cell Antitumor Activity. Blood, 140(Supplement 1), 10235-10236.

Chen, Y. G. (2022). Investigating the role of the linear ubiquitin chain assembly complex in lymphotoxin beta receptor signalling and obesity-derived hepatitis (Doctoral dissertation, UCL (University College London)).

Shou, Y., Koroleva, E., Spencer, C. M., Shein, S. A., Korchagina, A. A., Yusoof, K. A., ... & Tumanov, A. V. (2021). Redefining the role of lymphotoxin beta receptor in the maintenance of lymphoid organs and immune cell homeostasis in adulthood. Frontiers in immunology, 12, 712632.

Francipane, M. G., Han, B., & Lagasse, E. (2020). Host lymphotoxin-β receptor signaling is crucial for angiogenesis of metanephric tissue transplanted into lymphoid sites. The American Journal of Pathology, 190(1), 252-269.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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