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Hamster Anti-LY9 Recombinant Antibody (Ly9ab3) (CBMAB-C3451-CQ)

This product is a hamster antibody that recognizes LY9. The antibody Ly9ab3 can be used for immunoassay techniques such as: FC.
See all LY9 antibodies

Summary

Host Animal
Hamster
Specificity
Mouse
Clone
Ly9ab3
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
AHK cells transiently transfected with mouse CD229
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lymphocyte antigen 9
Introduction
LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490).
Entrez Gene ID
17085
UniProt ID
Q01965
Alternative Names
CD229; SLAMF3; hly9; mLY9
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).
Biological Process
Cell adhesionIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
T cell activationManual Assertion Based On ExperimentIBA:GO_Central
T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Cell membrane
Topology
Extracellular: 48-454
Helical: 455-476
Cytoplasmic: 477-655
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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