Mouse Recombinant LY9 protein, His Tag (V2LY-0526-LY7976)

Name: Mouse Recombinant LY9 protein, His Tag
SKU: V2LY-0526-LY7976
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant LY9 protein, His Tag consist of Amino Acid: 1-453 and predicts a molecular mass of 46.5 kDa.

Molecule Mass

46.5 kDa

Sequence

Amino Acid: 1-453

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Tween80

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Lymphocyte antigen 9

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).

Biological Process

Cell adhesionIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
T cell activationManual Assertion Based On ExperimentIBA:GO_Central
T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane
Cell membrane

Topology

Extracellular: 48-454
Helical: 455-476
Cytoplasmic: 477-655

Liu, Q., Deng, Y., Liu, X., Zheng, Y., Li, Q., Cai, G., ... & Chen, X. (2023). Transcriptomic analysis of B cells suggests that CD70 and LY9 may be novel features in patients with systemic lupus erythematosus. Heliyon, 9(5).

Deng, K., Xu, Z., Yuan, L., Qin, F., Zheng, Z., Huang, L., ... & Li, S. (2022). Lymphocyte Antigen 9 as a potential immunotherapeutic target and a new prognostic biomarker for lung adenocarcinoma.

Roncador, G., Puñet-Ortiz, J., Maestre, L., Rodríguez-Lobato, L. G., Jiménez, S., Reyes-García, A. I., ... & Engel, P. (2022). CD229 (Ly9) a novel biomarker for B-cell malignancies and multiple myeloma. Cancers, 14(9), 2154.

Angulo, A., Cuenca, M., Martínez-Vicente, P., & Engel, P. (2019). Viral CD229 (Ly9) homologs as new manipulators of host immunity. Journal of Leukocyte Biology, 105(5), 947-954.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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