Human LY9 ELISA Kit (V2LY-0626-LY5331)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0096 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
72.1 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Lymphocyte antigen 9
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).
Biological Process
Cell adhesionIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
T cell activationManual Assertion Based On ExperimentIBA:GO_Central
T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Cell membrane
Topology
Extracellular: 48-454
Helical: 455-476
Cytoplasmic: 477-655

Liu, Q., Deng, Y., Liu, X., Zheng, Y., Li, Q., Cai, G., ... & Chen, X. (2023). Transcriptomic analysis of B cells suggests that CD70 and LY9 may be novel features in patients with systemic lupus erythematosus. Heliyon, 9(5).

Deng, K., Xu, Z., Yuan, L., Qin, F., Zheng, Z., Huang, L., ... & Li, S. (2022). Lymphocyte Antigen 9 as a potential immunotherapeutic target and a new prognostic biomarker for lung adenocarcinoma.

Roncador, G., Puñet-Ortiz, J., Maestre, L., Rodríguez-Lobato, L. G., Jiménez, S., Reyes-García, A. I., ... & Engel, P. (2022). CD229 (Ly9) a novel biomarker for B-cell malignancies and multiple myeloma. Cancers, 14(9), 2154.

Angulo, A., Cuenca, M., Martínez-Vicente, P., & Engel, P. (2019). Viral CD229 (Ly9) homologs as new manipulators of host immunity. Journal of Leukocyte Biology, 105(5), 947-954.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant LY9 protein, His Tag (CAT#: V2LY-0526-LY7976)

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Isotype control

For research use only. Not intended for any clinical use.

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