Mouse Anti-LY9 Recombinant Antibody (CBXC-1043) (CBMAB-C1307-CQ)

Name: Mouse Anti-LY9 Recombinant Antibody (CBXC-1043)
SKU: CBMAB-C1307-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-1043

Application

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Lymphocyte antigen 9

Introduction

LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490).

Entrez Gene ID

4063

UniProt ID

Q9HBG7

Alternative Names

CD229; SLAMF3; hly9; mLY9

Function

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).

Biological Process

Cell adhesionIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
T cell activationManual Assertion Based On ExperimentIBA:GO_Central
T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane
Cell membrane

Topology

Extracellular: 48-454
Helical: 455-476
Cytoplasmic: 477-655

Liu, Q., Deng, Y., Liu, X., Zheng, Y., Li, Q., Cai, G., ... & Chen, X. (2023). Transcriptomic analysis of B cells suggests that CD70 and LY9 may be novel features in patients with systemic lupus erythematosus. Heliyon, 9(5).

Deng, K., Xu, Z., Yuan, L., Qin, F., Zheng, Z., Huang, L., ... & Li, S. (2022). Lymphocyte Antigen 9 as a potential immunotherapeutic target and a new prognostic biomarker for lung adenocarcinoma.

Roncador, G., Puñet-Ortiz, J., Maestre, L., Rodríguez-Lobato, L. G., Jiménez, S., Reyes-García, A. I., ... & Engel, P. (2022). CD229 (Ly9) a novel biomarker for B-cell malignancies and multiple myeloma. Cancers, 14(9), 2154.

Angulo, A., Cuenca, M., Martínez-Vicente, P., & Engel, P. (2019). Viral CD229 (Ly9) homologs as new manipulators of host immunity. Journal of Leukocyte Biology, 105(5), 947-954.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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