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Rabbit Anti-Ly9 Recombinant Antibody (CBYJL-2551) (CBMAB-L2975-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Lymphocyte Antigen 9 (Ly9). The antibody can be used for immunoassay techniques, such as FC.
See all Ly9 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBYJL-2551
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Recombinant Mouse Ly9/CD229/SLAMF3 protein.
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lymphocyte antigen 9
Introduction
Lymphocyte antigen 9 is a self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Its activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. It may participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. It promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A. It also promotes recruitment of RORC to the IL-17 promoter (By similarity). It may be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. It may disable autoantibody responses and inhibit IFN-gamma secretion by CD4+ T-cells. It may negatively regulate the size of thymic innate CD8+ T-cells and the development of invariant natural killer T (iNKT) cells. It can promote natural killer (NK) cell activation.
Entrez Gene ID
17085
UniProt ID
Q01965
Alternative Names
Ly-9; T100; CD229; Lgp100; SLAMF3; AI893573; T-lymphocyte surface antigen Ly-9; SLAM family member 3; cell surface molecule Ly-9; signaling lymphocytic activation molecule 3
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:22184727).
Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874).
May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells (By similarity).
Biological Process
Cell adhesionIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:UniProtKB
T cell activationManual Assertion Based On ExperimentIBA:GO_Central
T-helper 17 cell lineage commitmentManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Cell membrane
Topology
Extracellular: 48-454
Helical: 455-476
Cytoplasmic: 477-655
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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