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Recombinant Rabbit Anti-LYZ Antibody (CBAb157) (CBMAB-Ab157-LY)

The product is antibody recognizes LYZ. The antibody CBAb157 immunoassay techniques such as: WB 1:5000-1:10000; IHC 1:50-1:200; IF 1:50-1:200; IP 1:20-1:50.
See all LYZ antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBAb157
Antibody Isotype
IgG
Application
WB 1:5000-1:10000; IHC 1:50-1:200; IF 1:50-1:200; IP 1:20-1:50

Basic Information

Immunogen
Recombinant protein of human LYZ
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LYZ
Introduction
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis.
Entrez Gene ID
Human4069
Mouse17110
Rat25211
UniProt ID
HumanP61626
MouseP08905
RatP00697
Alternative Names
LYZ; LYZF1; LZM; lysozyme
Function
Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.
Biological Process
Antimicrobial humoral responseTAS:Reactome
CytolysisIEA:UniProtKB-KW
Defense response to bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Metabolic processIEA:UniProtKB-KW
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Secreted
Involvement in disease
Amyloidosis 8 (AMYL8):
A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.

Nawaz, N., Wen, S., Wang, F., Nawaz, S., Raza, J., Iftikhar, M., & Usman, M. (2022). Lysozyme and its application as antibacterial agent in food industry. Molecules, 27(19), 6305.

Hu, F., Wang, Y., Hu, J., Bao, Z., & Wang, M. (2022). A novel c-type lysozyme from Litopenaeus vannamei exhibits potent antimicrobial activity. Fish & Shellfish Immunology, 131, 729-735.

Moreno-Navarrete, J. M., Latorre, J., Lluch, A., Ortega, F. J., Comas, F., Arnoriaga-Rodríguez, M., ... & Fernández-Real, J. M. (2021). Lysozyme is a component of the innate immune system linked to obesity associated-chronic low-grade inflammation and altered glucose tolerance. Clinical Nutrition, 40(3), 1420-1429.

Li, L., Cardoso, J. C., Felix, R. C., Mateus, A. P., Canário, A. V., & Power, D. M. (2021). Fish lysozyme gene family evolution and divergent function in early development. Developmental & Comparative Immunology, 114, 103772.

Latorre, J., Lluch, A., Ortega, F. J., Gavaldà-Navarro, A., Comas, F., Morón-Ros, S., ... & Moreno-Navarrete, J. M. (2021). Adipose tissue knockdown of lysozyme reduces local inflammation and improves adipogenesis in high-fat diet-fed mice. Pharmacological Research, 166, 105486.

Wang, H., Shen, X., Zheng, X., Pan, Y., Zhang, Q., & Liu, Z. (2021). Intestinal lysozyme releases Nod2 ligand (s) to promote the intestinal mucosal adjuvant activity of cholera toxin. Science China Life Sciences, 64, 1720-1731.

Yu, S., Balasubramanian, I., Laubitz, D., Tong, K., Bandyopadhyay, S., Lin, X., ... & Gao, N. (2020). Paneth cell-derived lysozyme defines the composition of mucolytic microbiota and the inflammatory tone of the intestine. Immunity, 53(2), 398-416.

Jin, Y., Zeng, Q., Geng, F., & Ma, M. (2020). Characterization of the interaction between hen egg white lysozyme and ovalbumin: Interaction between lysozyme and ovalbumin. Food Bioscience, 36, 100674.

Li, H., Wei, X., Yang, J., Zhang, R., Zhang, Q., & Yang, J. (2019). The bacteriolytic mechanism of an invertebrate-type lysozyme from mollusk Octopus ocellatus. Fish & Shellfish Immunology, 93, 232-239.

Iwashita, K., Handa, A., & Shiraki, K. (2019). Co-aggregation of ovotransferrin and lysozyme. Food Hydrocolloids, 89, 416-424.

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For research use only. Not intended for any clinical use.

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