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Mouse Anti-LZTS2 Recombinant Antibody (CBYJL-2291) (CBMAB-L2576-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Zipper Tumor Suppressor 2 (LZTS2). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all LZTS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJL-2291
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucine zipper tumor suppressor 2
Introduction
The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
Human84445
Mouse226154
Rat365468
UniProt ID
HumanQ9BRK4
MouseQ91YU6
RatQ3LUD4
Alternative Names
LAPSER1
Function
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Biological Process
Microtubule severingIEA:UniProtKB-UniRule
Mitotic cytokinesisIEA:UniProtKB-UniRule
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of protein localization to nucleusIEA:Ensembl
Nuclear exportIEA:UniProtKB-UniRule
Primary ureteric bud growthIEA:Ensembl
Spindle midzone assemblyIEA:UniProtKB-UniRule
Ureter morphogenesisIEA:Ensembl
Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.

Wang, Y., Yemelyanov, A., Go, C. D., Kim, S., Quinn, J. M., Flozak, A. S., ... & Gottardi, C. J. (2023). α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2. bioRxiv.

Ji, H., Yang, T., Li, C., Zhu, Y., Zheng, Z., Zhang, J., ... & Xue, F. (2023). EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post-transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis. Biochemical Pharmacology, 214, 115676.

Dong, Z., Li, J., Dai, W., Yu, D., Zhao, Y., Liu, S., ... & Ding, C. (2023). RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression. Cell Death & Disease, 14(2), 89.

Gunnin, R., Witt BS, A., & Litovchick, M. D. (2023). Investigation of the DYRK1A Regulation by LZTS2-SIPA1L1 Complex.

Zhang, J., Zhang, L., Wang, J., Zhao, J., Zhao, X., Zhang, C., ... & Geng, C. (2022). Long non-coding RNA linc00921 suppresses tumorigenesis and epithelial-to-mesenchymal transition of triple-negative breast cancer via targeting miR-9-5p/LZTS2 axis. Human Cell, 35(3), 909-923.

Peng, Y., Greenland, N. Y., Lang, U. E., & Stohr, B. A. (2022). LZTS2: A novel and independent prognostic biomarker for clear cell renal cell carcinoma. Pathology-Research and Practice, 232, 153831.

Lu, Y., Li, X., Liu, H., Xue, J., Zeng, Z., Dong, X., ... & Xu, S. (2021). β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma. Oncogene, 40(7), 1269-1283.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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