LZTS2

The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants.

Full Name

leucine zipper tumor suppressor 2

Function

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

Biological Process

Microtubule severingIEA:UniProtKB-UniRule
Mitotic cytokinesisIEA:UniProtKB-UniRule
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of protein localization to nucleusIEA:Ensembl
Nuclear exportIEA:UniProtKB-UniRule
Primary ureteric bud growthIEA:Ensembl
Spindle midzone assemblyIEA:UniProtKB-UniRule
Ureter morphogenesisIEA:Ensembl
Wnt signaling pathwayIEA:UniProtKB-KW

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.