Rabbit Anti-MAD2L2 Recombinant Antibody (
4D8) (V2LY-0725-LY1354)

MITOTIC ARREST DEFICIENT 2 LIKE 2

Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893).
Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194).
Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194).
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893).
During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893).
Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730).
Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540).
Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654).

Actin filament organizationManual Assertion Based On ExperimentIMP:BHF-UCL
Cell divisionIEA:UniProtKB-KW
DNA damage response, signal transduction resulting in transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Double-strand break repairManual Assertion Based On ExperimentIGI:UniProtKB
Error-prone translesion synthesisManual Assertion Based On ExperimentIDA:ComplexPortal
Mitotic spindle assembly checkpoint signalingManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by competitive promoter bindingManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of ubiquitin protein ligase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of isotype switchingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell growthManual Assertion Based On ExperimentIGI:UniProtKB
Somatic diversification of immunoglobulins involved in immune response1 PublicationIC:ComplexPortal
Telomere maintenance in response to DNA damage1 PublicationIC:ComplexPortal

Nucleus
Cytoplasm, cytoskeleton, spindle
Cytoplasm
Chromosome
Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.

Fanconi anemia, complementation group V (FANCV):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.