MAD2L2

The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.

MITOTIC ARREST DEFICIENT 2 LIKE 2

Adapter protein able to interact with different proteins and involved in different biological processes (PubMed:11459825, PubMed:11459826, PubMed:17719540, PubMed:17296730, PubMed:19443654, PubMed:29656893).
Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:20164194).
Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions (PubMed:20164194).
Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893).
During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893).
Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893).
May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1 (PubMed:17296730).
Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle (PubMed:11459825, PubMed:17719540).
Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation (PubMed:19443654).

Actin filament organizationManual Assertion Based On ExperimentIMP:BHF-UCL
Cell divisionIEA:UniProtKB-KW
DNA damage response, signal transduction resulting in transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Double-strand break repairManual Assertion Based On ExperimentIGI:UniProtKB
Error-prone translesion synthesisManual Assertion Based On ExperimentIDA:ComplexPortal
Mitotic spindle assembly checkpoint signalingManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of cell-cell adhesion mediated by cadherinManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of DNA-binding transcription factor activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription by competitive promoter bindingManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of transcription regulatory region DNA bindingManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of ubiquitin protein ligase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of isotype switchingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cell growthManual Assertion Based On ExperimentIGI:UniProtKB
Somatic diversification of immunoglobulins involved in immune response1 PublicationIC:ComplexPortal
Telomere maintenance in response to DNA damage1 PublicationIC:ComplexPortal

Nucleus
Cytoplasm, cytoskeleton, spindle
Cytoplasm
Chromosome
Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle.

Fanconi anemia, complementation group V (FANCV):
A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.