Mouse Anti-MAFB Antibody (1A10) (CBMAB-0629-YC)
Compare
Online Inquiry
Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity).
Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).
Brain segmentationIEA:Ensembl
Cornified envelope assemblyIEA:Ensembl
Fat cell differentiationISS:UniProtKB
Inner ear morphogenesisIEA:Ensembl
Integrated stress response signaling1 PublicationIC:ComplexPortal
Keratinocyte differentiationIEA:Ensembl
Negative regulation of erythrocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of osteoclast differentiationISS:UniProtKB
Positive regulation of transcription, DNA-templatedISS:UniProtKB
Protein processingIEA:Ensembl
Regulation of myeloid cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Respiratory gaseous exchange by respiratory systemIEA:Ensembl
Rhombomere 5 developmentIEA:Ensembl
Rhombomere 6 developmentIEA:Ensembl
Segment specificationIEA:Ensembl
Sensory organ developmentManual Assertion Based On ExperimentTAS:ProtInc
T cell differentiation in thymusIEA:Ensembl
Thymus developmentIEA:Ensembl
A rare skeletal disorder, usually presenting in early childhood with a clinical picture mimicking juvenile rheumatoid arthritis. Progressive destruction of the carpal and tarsal bone usually occurs and other bones may also be involved. Chronic renal failure is a frequent component of the syndrome. Mental retardation and minor facial anomalies have been noted in some patients.
Duane retraction syndrome 3 with or without deafness (DURS3):
A form of Duane retraction syndrome, a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction or both, narrowing of the palpebral fissure, and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision. Some DURS3 patients manifest sensorineural hearing loss.
Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon
$30 eGift Card
Submit a review
Loading...
Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Related Products
Rabbit Anti-MAFB Recombinant Antibody (CBR046F) (CAT#: CBMAB-BT055LY)
Mouse Anti-MAFB (AA 32-320 ) Recombinant Antibody (CBFYM-1280) (CAT#: CBMAB-M1439-FY)
Mouse Anti-MAFB Recombinant Antibody (CBFYM-1279) (CAT#: CBMAB-M1438-FY)
Mouse Anti-MAFB Recombinant Antibody (CBFYM-1282) (CAT#: CBMAB-M1441-FY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
Online InquiryContact us
