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Mouse Anti-MAGED2 Recombinant Antibody (1B5) (CBMAB-A5170-LY)

The product is antibody recognizes MAGED2. The antibody 1B5 immunoassay techniques such as: WB, ELISA.
See all MAGED2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
MAGED2 (NP_055414, 16 a.a. ~ 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
melanoma antigen family D, 2
Introduction
This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked mental retardation (XLMR). Multiple alternatively spliced transcript variants have been found for this gene, however, the full length nature of some variants has not been defined. [provided by RefSeq]
Entrez Gene ID
10916
UniProt ID
Q9UNF1
Alternative Names
11B6; BCG1; HCA10; JCL-1; MAGE-D2; MAGED; MGC8386
Function
Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.
Biological Process
Female pregnancyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Renal sodium ion absorptionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytosol
Extracellular region
Membrane
Nucleolus
Nucleoplasm
Nucleus
Platelet alpha granule lumen
Involvement in disease
Bartter syndrome 5, antenatal, transient (BARTS5):
An X-linked recessive form of Bartter syndrome, a disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS5 is an antenatal form beginning in utero with marked fetal polyuria that leads to polyhydramnios and premature delivery. It is characterized by severe but transient symptoms that can resolve with age.

Walsh, C. J., Micke, K., Elfman, H., Bock, M., Harper, T., Zaretsky, M., ... & Putra, M. (2023). Successful antenatal treatment of MAGED2‐related Bartter syndrome and review of treatment options and efficacy. Prenatal Diagnosis.

Shi, X., Liu, C., Zheng, W., Cao, X., Li, W., Zhang, D., ... & Chen, Y. (2023). Proteomic analysis revealed the potential role of MAGE-D2 in the therapeutic targeting of triple-negative breast cancer. Molecular & Cellular Proteomics, 100703.

Ju, X., Wang, Z., Wang, P., Ren, W., Yu, Y., Yu, Y., ... & Ding, Q. (2023). SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. Mbio, 14(4), e01373-23.

Seaayfan, E., Nasrah, S., Quell, L., Kleim, M., Weber, S., Meyer, H., ... & Kömhoff, M. (2022). MAGED2 is required under hypoxia for cAMP signaling by inhibiting MDM2-dependent endocytosis of G-Alpha-S. Cells, 11(16), 2546.

Seaayfan, E., Nasrah, S., Quell, L., Radi, A., Kleim, M., Schermuly, R. T., ... & Kömhoff, M. (2022). Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II. Cells, 11(21), 3424.

Reusch, B., Bartram, M. P., Dafinger, C., Palacio-Escat, N., Wenzel, A., Fenton, R. A., ... & Rinschen, M. M. (2022). MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells. Journal of proteomics, 252, 104424.

Wu, X., Huang, L., Luo, C., Liu, Y., & Niu, J. (2021). A case report and literature review of a novel mutation in the MAGED2 gene of a patient with severe transient polyhydramnios. Frontiers in Pediatrics, 9, 778814.

Ma, M., Zhang, M., Zhou, Y., Yao, F., Wei, M., Li, Z., & Qiu, Z. (2021). A novel MAGED2 variant in a Chinese preterm newborn with transient antenatal Bartter’s syndrome with 4 years follow-up. BMC nephrology, 22(1), 1-4.

Mansor, S., Kuick, C. H., Lim-Tan, S. K., Leong, M. Y., Lim, T. Y. K., & Chang, K. T. E. (2020). 28. Novel fusion MAGED2-PLAG1 in endometrial stromal sarcoma. Pathology, 52, S142-S143.

Valino-Rivas, L., Cuarental, L., Agustin, M., Husi, H., Cannata-Ortiz, P., Sanz, A. B., ... & Sanchez-Niño, M. D. (2019). MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells. Nephrology Dialysis Transplantation, 34(9), 1498-1507.

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For research use only. Not intended for any clinical use.

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