Sign in or Register   Sign in or Register
  |  

Mouse Anti-MAGED2 (AA 16-125) Recombinant Antibody (CBFYM-1333) (CBMAB-M1492-FY)

This product is mouse antibody that recognizes MAGED2. The antibody CBFYM-1333 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all MAGED2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-1333
Antibody Isotype
IgG2a, k
Application
ELISA, IF, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: AEASEKDSSS MMQTLLTVTQ NVEVPETPKA SKALEVSEDV KVSKASGVSK ATEVSKTPEA REAPATQASS TTQLTDTQVL AAENKSLAAD TKKQNADPQA VTMPATETKK
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 16-125

Target

Full Name
melanoma antigen family D, 2
Introduction
This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability. Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
10916
UniProt ID
Q9UNF1
Alternative Names
MAGE Family Member D2; Hepatocellular Carcinoma-Associated Protein JCL-1; Breast Cancer-Associated Gene 1 Protein; Melanoma-Associated Antigen D2; Melanoma Antigen Family D2; MAGE-D2 Antigen; BCG-1; 11B6; BCG1
Function
Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule.
Biological Process
Female pregnancyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Renal sodium ion absorptionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytosol
Extracellular region
Membrane
Nucleolus
Nucleoplasm
Nucleus
Platelet alpha granule lumen
Involvement in disease
Bartter syndrome 5, antenatal, transient (BARTS5):
An X-linked recessive form of Bartter syndrome, a disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BARTS5 is an antenatal form beginning in utero with marked fetal polyuria that leads to polyhydramnios and premature delivery. It is characterized by severe but transient symptoms that can resolve with age.

Walsh, C. J., Micke, K., Elfman, H., Bock, M., Harper, T., Zaretsky, M., ... & Putra, M. (2023). Successful antenatal treatment of MAGED2‐related Bartter syndrome and review of treatment options and efficacy. Prenatal Diagnosis.

Shi, X., Liu, C., Zheng, W., Cao, X., Li, W., Zhang, D., ... & Chen, Y. (2023). Proteomic analysis revealed the potential role of MAGE-D2 in the therapeutic targeting of triple-negative breast cancer. Molecular & Cellular Proteomics, 100703.

Ju, X., Wang, Z., Wang, P., Ren, W., Yu, Y., Yu, Y., ... & Ding, Q. (2023). SARS-CoV-2 main protease cleaves MAGED2 to antagonize host antiviral defense. Mbio, 14(4), e01373-23.

Seaayfan, E., Nasrah, S., Quell, L., Kleim, M., Weber, S., Meyer, H., ... & Kömhoff, M. (2022). MAGED2 is required under hypoxia for cAMP signaling by inhibiting MDM2-dependent endocytosis of G-Alpha-S. Cells, 11(16), 2546.

Seaayfan, E., Nasrah, S., Quell, L., Radi, A., Kleim, M., Schermuly, R. T., ... & Kömhoff, M. (2022). Reciprocal Regulation of MAGED2 and HIF-1α Augments Their Expression under Hypoxia: Role of cAMP and PKA Type II. Cells, 11(21), 3424.

Reusch, B., Bartram, M. P., Dafinger, C., Palacio-Escat, N., Wenzel, A., Fenton, R. A., ... & Rinschen, M. M. (2022). MAGED2 controls vasopressin-induced aquaporin-2 expression in collecting duct cells. Journal of proteomics, 252, 104424.

Wu, X., Huang, L., Luo, C., Liu, Y., & Niu, J. (2021). A case report and literature review of a novel mutation in the MAGED2 gene of a patient with severe transient polyhydramnios. Frontiers in Pediatrics, 9, 778814.

Ma, M., Zhang, M., Zhou, Y., Yao, F., Wei, M., Li, Z., & Qiu, Z. (2021). A novel MAGED2 variant in a Chinese preterm newborn with transient antenatal Bartter’s syndrome with 4 years follow-up. BMC nephrology, 22(1), 1-4.

Mansor, S., Kuick, C. H., Lim-Tan, S. K., Leong, M. Y., Lim, T. Y. K., & Chang, K. T. E. (2020). 28. Novel fusion MAGED2-PLAG1 in endometrial stromal sarcoma. Pathology, 52, S142-S143.

Valino-Rivas, L., Cuarental, L., Agustin, M., Husi, H., Cannata-Ortiz, P., Sanz, A. B., ... & Sanchez-Niño, M. D. (2019). MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells. Nephrology Dialysis Transplantation, 34(9), 1498-1507.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MAGED2 (AA 16-125) Recombinant Antibody (CBFYM-1333)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare