Rabbit Anti-MAML1 Recombinant Antibody (CBFYM-1353) (CBMAB-M1512-FY)

Name: Rabbit Anti-MAML1 Recombinant Antibody (CBFYM-1353)
SKU: CBMAB-M1512-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYM-1353

Application

IP, WB

Immunogen

Synthetic peptide corresponding to residues surrounding Asp269 of human MAML1

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HEPES, pH 7.5, 0.15 M NaCl, 0.01% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Mastermind Like Transcriptional Coactivator 1

Introduction

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Entrez Gene ID

Human	9794
Mouse	103806
Rat	303101

UniProt ID

Human	Q92585
Mouse	Q6T264
Rat	D4A930

Alternative Names

Mastermind Like Transcriptional Coactivator 1; Mastermind Homolog; Mam-1; Mastermind (Drosophila)-Like 1; Mastermind-Like 1 (Drosophila); Mastermind-Like Protein 1; Mastermind-Like 1; KIAA0200; Mam1

Function

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Biological Process

Atrioventricular node cell developmentISS:BHF-UCL
Atrioventricular node developmentISS:BHF-UCL
Myoblast differentiationIEA:Ensembl
Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of myotube differentiationManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription of Notch receptor targetManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus speckle
Nuclear, in a punctate manner.

Warmke, L. M., Collier, C. D., & Davis, J. L. (2023). NR1D1:: MAML1 epithelioid and spindle cell sarcoma mimicking pseudomyogenic hemangioendothelioma in core biopsy: A case report and review of the literature. Genes, Chromosomes and Cancer, 62(11), 655-662.

Hamidi, A. A., Forghanifard, M. M., Gholamin, M., Moghbeli, M., Memar, B., Jangjoo, A., ... & Abbaszadegan, M. R. (2022). Elucidated tumorigenic role of MAML1 and TWIST1 in gastric cancer is associated with Helicobacter pylori infection. Microbial Pathogenesis, 162, 105304.

Zafir, S., Zhou, W., Menkhorst, E., Santos, L., & Dimitriadis, E. (2021). MAML1: a coregulator that alters endometrial epithelial cell adhesive capacity. Fertility Research and Practice, 7(1), 1-11.

Kim, J., Kwon, H., Shin, Y. K., Song, G., Lee, T., Kim, Y., ... & Jho, E. H. (2020). MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis. Proceedings of the National Academy of Sciences, 117(24), 13529-13540.

Forghanifard, M. M., Azaraz, S., Ardalan Khales, S., Morshedi Rad, D., & Abbaszadegan, M. R. (2020). MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1. Molecular biology reports, 47, 2659-2668.

Razavi, S. M. S., Forghanifard, M. M., Kordi-Tamandani, D. M., & Abbaszadegan, M. R. (2019). MAML1 regulates EMT markers expression through NOTCH-independent pathway in breast cancer cell line MCF7. Biochemical and biophysical research communications, 510(3), 376-382.

Shi, W., Tang, T., Li, X., Deng, S., Li, R., Wang, Y., ... & Pan, Y. (2019). Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop. Journal of Experimental & Clinical Cancer Research, 38(1), 1-20.

Moghbeli, M., Mosannen Mozaffari, H., Memar, B., Forghanifard, M. M., Gholamin, M., & Abbaszadegan, M. R. (2019). Role of MAML1 in targeted therapy against the esophageal cancer stem cells. Journal of translational medicine, 17(1), 1-12.

Jia, D., Underwood, J., Xu, Q., & Xie, Q. (2019). NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer. Oncology Letters, 17(6), 4914-4920.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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