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Rabbit Anti-MAML1 Recombinant Antibody (D3E9) (CBMAB-CP1434-LY)

The product is antibody recognizes MAML1. The antibody D3E9 immunoassay techniques such as: WB,IP,CIP.
See all MAML1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D3E9
Antibody Isotype
IgG
Application
WB, IP, CIP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAML1 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Mastermind Like Transcriptional Coactivator 1
Introduction
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9794
Mouse103806
Rat303101
Monkey715047
UniProt ID
HumanQ92585
MouseQ6T264
RatD4A930
MonkeyA0A0D9R7N6
Alternative Names
Mastermind Like Transcriptional Coactivator 1; Mastermind Homolog; Mam-1; Mastermind (Drosophila)-Like 1; Mastermind-Like 1 (Drosophila); Mastermind-Like Protein 1; Mastermind-Like 1; KIAA0200; Mam1;
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Biological Process
Atrioventricular node cell developmentISS:BHF-UCL
Atrioventricular node developmentISS:BHF-UCL
Myoblast differentiationIEA:Ensembl
Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of myotube differentiationManual Assertion Based On ExperimentIGI:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription of Notch receptor targetManual Assertion Based On ExperimentIBA:GO_Central
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus speckle
Nuclear, in a punctate manner.

Warmke, L. M., Collier, C. D., & Davis, J. L. (2023). NR1D1:: MAML1 epithelioid and spindle cell sarcoma mimicking pseudomyogenic hemangioendothelioma in core biopsy: A case report and review of the literature. Genes, Chromosomes and Cancer, 62(11), 655-662.

Hamidi, A. A., Forghanifard, M. M., Gholamin, M., Moghbeli, M., Memar, B., Jangjoo, A., ... & Abbaszadegan, M. R. (2022). Elucidated tumorigenic role of MAML1 and TWIST1 in gastric cancer is associated with Helicobacter pylori infection. Microbial Pathogenesis, 162, 105304.

Zafir, S., Zhou, W., Menkhorst, E., Santos, L., & Dimitriadis, E. (2021). MAML1: a coregulator that alters endometrial epithelial cell adhesive capacity. Fertility Research and Practice, 7(1), 1-11.

Kim, J., Kwon, H., Shin, Y. K., Song, G., Lee, T., Kim, Y., ... & Jho, E. H. (2020). MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis. Proceedings of the National Academy of Sciences, 117(24), 13529-13540.

Forghanifard, M. M., Azaraz, S., Ardalan Khales, S., Morshedi Rad, D., & Abbaszadegan, M. R. (2020). MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1. Molecular biology reports, 47, 2659-2668.

Razavi, S. M. S., Forghanifard, M. M., Kordi-Tamandani, D. M., & Abbaszadegan, M. R. (2019). MAML1 regulates EMT markers expression through NOTCH-independent pathway in breast cancer cell line MCF7. Biochemical and biophysical research communications, 510(3), 376-382.

Shi, W., Tang, T., Li, X., Deng, S., Li, R., Wang, Y., ... & Pan, Y. (2019). Methylation-mediated silencing of miR-133a-3p promotes breast cancer cell migration and stemness via miR-133a-3p/MAML1/DNMT3A positive feedback loop. Journal of Experimental & Clinical Cancer Research, 38(1), 1-20.

Moghbeli, M., Mosannen Mozaffari, H., Memar, B., Forghanifard, M. M., Gholamin, M., & Abbaszadegan, M. R. (2019). Role of MAML1 in targeted therapy against the esophageal cancer stem cells. Journal of translational medicine, 17(1), 1-12.

Jia, D., Underwood, J., Xu, Q., & Xie, Q. (2019). NOTCH2/NOTCH3/DLL3/MAML1/ADAM17 signaling network is associated with ovarian cancer. Oncology Letters, 17(6), 4914-4920.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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