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Mouse Anti-MAML3 Recombinant Antibody (MAML3/1303) (CBMAB-M0431-FY)

This product is mouse antibody that recognizes MAML3. The antibody MAML3/1303 can be used for immunoassay techniques such as: FC, IHC-P, IF.
See all MAML3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
MAML3/1303
Antibody Isotype
IgG1
Application
FC, IHC-P, IF

Basic Information

Immunogen
Recombinant human MAML3 protein fragment
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MASTERMIND LIKE TRANSCRIPTIONAL COACTIVATOR 3
Introduction
MAML3 is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and PI3K-Akt signaling pathway. Gene Ontology annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAML1.
Entrez Gene ID
55534
UniProt ID
Q96JK9
Alternative Names
Mastermind Like Transcriptional Coactivator 3; Trinucleotide Repeat Containing 3; MAM-3; CAG Repeat Containing (Glia-Derived Nexin I Alpha); Expanded Repeat Domain, CAG/CTG 3; Mastermind (Drosophila)-Like 3; Mastermind-Like 3 (Drosophila); Mastermind-Like Protein 3; Polyglutamine Rich; CAG Repeat Domain
Function
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Biological Process
Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription of Notch receptor targetManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus speckle
Nuclear, in a punctate manner.

Li, P., & Busam, K. J. (2023). Spindle cell porocarcinoma with a novel YAP1:: MAML3 fusion. Journal of Cutaneous Pathology.

Na, L., Onishi, H., Morisaki, S., Ichimiya, S., Yamada, Y., Masuda, S., ... & Nakamura, M. (2023). MAML3 Contributes to Induction of Malignant Phenotype of Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia. Anticancer Research, 43(7), 2909-2922.

Meyer, A., Klubíčková, N., Mosaieby, E., Grossmann, P., Kalmykova, A., Koshyk, O., & Michal, M. (2023). Biphenotypic sinonasal sarcoma with PAX3:: MAML3 fusion transforming into high-grade rhabdomyosarcoma: report of an emerging rare phenomenon. Virchows Archiv, 482(4), 777-782.

Monteagudo, M., Calsina, B., Martínez-Montes, Á. M., Piñeiro-Yáñez, E., Caleiras, E., Martín, M. C., ... & Robledo, M. (2023). MAML3-fusions modulate Vascular and Immune Tumor Microenvironment and Confer High Metastatic Risk in Pheochromocytoma and Paraganglioma.

Zha, Q., Wu, X., Zhang, J., Xu, T., Shi, Y., Sun, Y., ... & Tian, S. (2022). Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis. Cell Death Discovery, 8(1), 144.

Alzofon, N., Koc, K., Panwell, K., Pozdeyev, N., Marshall, C. B., Albuja-Cruz, M., ... & Fishbein, L. (2021). Mastermind like transcriptional coactivator 3 (MAML3) drives neuroendocrine tumor progression. Molecular Cancer Research, 19(9), 1476-1485.

Smestad, J. A., & Maher, L. J. (2019). Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations. Bmc Cancer, 19(1), 1-19.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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